ArticleJournal of the Royal Society, Interface2023
Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.
Article in Journal of the Royal Society, Interface, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Topological criterion for robust perfect adaptation of reaction fluxes in biological networks.iScience · 2025Article
- Laser capture microdissection.Nature reviews. Methods primers · 2025Article
- A distributed integral control mechanism for regulation of cholesterol concentration in the human retina.Royal Society open science · 2024Article
- Only a topological method can identify all possible network structures capable of Robust Perfect Adaptation.PLoS computational biology · 2023Article
- Universal structures for adaptation in biochemical reaction networks.Nature communications · 2023Article
- Robust homeostasis of cellular cholesterol is a consequence of endogenous antithetic integral control.Frontiers in cell and developmental biology · 2023Article
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Authors and funding
2 authors.
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Abstract
Robust perfect adaptation (RPA) is a ubiquitously observed signalling response across all scales of biological organization. A major class of network architectures that drive RPA in complex networks is the Opposer module-a feedback-regulated network into which specialized integral-computing 'opposer node(s)' are embedded. Although ultrasensitivity-generating chemical reactions have long been considered a possible mechanism for such adaptation-conferring opposer nodes, this hypothesis has relied on simplified Michaelian models, which neglect the presence of protein-protein complexes. Here we develop
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