Evidence map›Paper›PMID 36596421›Full record

ArticleThe Science of the total environment2023

Multiple stressor effects on a model soil nematode, Caenorhabditis elegans: Combined effects of the pathogen Klebsiella pneumoniae and zinc oxide nanoparticles.

Jarad P Cochran, Jason M Unrine, Mark Coyne, Olga V Tsyusko

Open access · greenAbstract read
In one paragraph

Article in The Science of the total environment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jarad P CochranDepartment of Plant and Soil Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA.
Jason M UnrineDepartment of Plant and Soil Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA; Kentucky Water Resources Research Institute, University of Kentucky, Lexington, KY, USA.
Mark CoyneDepartment of Plant and Soil Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA.
Olga V TsyuskoDepartment of Plant and Soil Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA. Electronic address: olga.tsyusko@uky.edu.
University of Kentucky · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Pilot Project ProgramP30ES026529 · NIEHS · UNIVERSITY OF KENTUCKY · PI Jason Unrine · 2017 to 2026
$15.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIEHS NIH HHS P30 ES026529NIGMS NIH HHS P20 GM103436NIH HHS P40 OD010440
6 · The paper itself

Abstract

Research utilizing the model soil nematode Caenorhabditis elegans has revealed that agriculturally relevant nanoparticles (NP), such as zinc oxide NP (ZnONP), cause toxicity at low concentrations and disrupt molecular pathways of pathogen resistance. However, in most nanotoxicity assessments, model organisms are exposed to a single stressor but in nature organisms are affected by multiple sources of stress, including infections, which might exacerbate or mitigate negative effects of NP exposure. Thus, to expand our understanding of the environmental consequences of released NP, this project examined the synergistic/antagonistic effects of ZnONP on C. elegans infected with a common pathogen, Klebsiella pneumoniae. Individual exposures of C. elegans to ZnONP, zinc sulfate (Zn

Indexed as

NanoparticlesZinc OxideAnimalsCaenorhabditis elegansIonsKlebsiella pneumoniaeSoilIonsSoilZinc OxideAntagonistic effectsBiofilmInternal colonizationMultiple stressorsNanomaterialsToxicity

Identifiers

PMID36596421
PMCPMC9896629
OpenAlexW4313397800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.