Evidence map›Paper›PMID 36596265›Full record

ArticleJournal of inorganic biochemistry2023

Ruthenium pincer complexes for light activated toxicity: Lipophilic groups enhance toxicity.

Yifei Sun, Sanjit Das, Spenser R Brown, Emily R Blevins, Fengrui Qu, Nicholas A Ward, Shawn Aiden Gregory, Chance M Boudreaux, Yonghyun Kim, Elizabeth T Papish

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Half-Sandwich Type Platinum-Group Metal Complexes ofMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yifei SunThe University of Alabama, Department of Chemical and Biological Engineering, Tuscaloosa, AL 35487, USA.
Sanjit DasThe University of Alabama, Department of Chemistry and Biochemistry, Tuscaloosa, AL 35487, USA.
Spenser R BrownThe University of Alabama, Department of Chemical and Biological Engineering, Tuscaloosa, AL 35487, USA.
Emily R BlevinsThe University of Alabama, Department of Chemistry and Biochemistry, Tuscaloosa, AL 35487, USA.
Fengrui QuThe University of Alabama, Department of Chemical and Biological Engineering, Tuscaloosa, AL 35487, USA.
Nicholas A WardThe University of Alabama, Department of Chemistry and Biochemistry, Tuscaloosa, AL 35487, USA.
Shawn Aiden GregoryThe University of Alabama, Department of Chemistry and Biochemistry, Tuscaloosa, AL 35487, USA.
Chance M BoudreauxThe University of Alabama, Department of Chemistry and Biochemistry, Tuscaloosa, AL 35487, USA.
Yonghyun KimThe University of Alabama, Department of Chemical and Biological Engineering, Tuscaloosa, AL 35487, USA. Electronic address: ykim@eng.ua.edu.
Elizabeth T PapishThe University of Alabama, Department of Chemistry and Biochemistry, Tuscaloosa, AL 35487, USA. Electronic address: etpapish@ua.edu.
University of Alabama · US

Funding

Singlet oxygen formation vs. photodissociation for protic ruthenium anticancer compounds: The oxygenated substituent determines the mode of action and the cytotoxicityR15GM132803 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI PAPISH, ELIZABETH TABITHA · 2019 to 2022
$844k
NIGMS NIH HHS R15 GM132803
6 · The paper itself

Abstract

Nine ruthenium CNC pincer complexes (1-9) were tested for anticancer activity in cell culture under both dark and light conditions. These complexes included varied CNC pincer ligands including OH, OMe, or Me substituents on the pyridyl ring and wingtip N-heterocyclic carbene (NHC) groups which varied as methyl (Me), phenyl (Ph), mesityl (Mes), and 2,6-diisopropylphenyl (Dipp). The supporting ligands included acetonitrile, Cl, and 2,2'-bipyridine (bpy) donors. The synthesis of complexes 8 and 9 is described herein and are fully characterized by spectroscopic (

Indexed as

RutheniumHumansLigandsMagnetic Resonance SpectroscopyMethanePentamidine1,3-di(4-imidazolinophenoxyl)propanecarbeneLigandsMethanePentamidineRutheniumAnticancerLight activationLipophilic ligandsN-heterocyclic carbenesPincer ligandsRuthenium

Identifiers

PMID36596265
PMCPMC10231263
OpenAlexW4312084070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.