Evidence map›Paper›PMID 36595704›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

AIM2 sensors mediate immunity to

Camila Marques-da-Silva, Barun Poudel, Rodrigo P Baptista, Kristen Peissig, Lisa S Hancox, Justine C Shiau, Lecia L Pewe, Melanie J Shears, Thirumala-Devi Kanneganti, Photini Sinnis and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Camila Marques-da-SilvaDepartment of Cellular Biology, University of Georgia, Athens, GA 30605.
Barun PoudelDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242.
Rodrigo P BaptistaCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30605.
Kristen PeissigDepartment of Cellular Biology, University of Georgia, Athens, GA 30605.
Lisa S HancoxDepartment of Pathology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0003-1940-2619
Justine C ShiauCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30605.ORCID 0000-0002-5125-5156
Lecia L PeweDepartment of Pathology, University of Iowa, Iowa City, IA 52242.
Melanie J ShearsJohns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205.
Thirumala-Devi KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Photini SinnisJohns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0003-2954-7547
Dennis E KyleDepartment of Cellular Biology, University of Georgia, Athens, GA 30605.
Prajwal GurungDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242.
John T HartyDepartment of Pathology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0001-7266-2802
Samarchith P KurupDepartment of Cellular Biology, University of Georgia, Athens, GA 30605.ORCID 0000-0002-0640-0502
University of Georgia · USUniversity of Iowa · USJohns Hopkins University · USSt. Jude Children's Research Hospital · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Memory CD8 T cell immunity to Plasmodium liver stage infecR01AI085515 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2010 to 2020
$4.1M
Understanding immune regulation in blood-stage malariaR01AI100527 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2021
$3.6M
The Skin Phase of Malaria Infection (Sharon Patray Diversity Supplement)R01AI132359 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SINNIS, PHOTINI · 2017 to 2021
$2.7M
T cell immunity to Plasmodium sporozoite immunizationR01AI095178 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2012 to 2016
$2.6M
Implicating a previously unknown Dectin1-RIPK2-CARD9 signaling in providing resistance against Leishmania major infectionR01AI155425 · NIAID · UNIVERSITY OF IOWA · PI GURUNG, PRAJWAL · 2021 to 2025
$2.5M
Type-I Interferons drive cell-autonomous immunity to malariaR01AI168307 · NIAID · UNIVERSITY OF GEORGIA · PI KURUP, SAM · 2022 to 2025
$1.9M
Elucidating CD47-SHP1 biology to understand autoinflammatory disordersR21AI148904 · NIAID · UNIVERSITY OF IOWA · PI GURUNG, PRAJWAL · 2020 to 2021
$386k
Elucidating cellular and molecular mechanisms regulating SHP1-mediated inflammatory skin diseaseK22AI127836 · NIAID · UNIVERSITY OF IOWA · PI GURUNG, PRAJWAL · 2018 to 2019
$269k
NCI NIH HHS P30 CA086862NIAID NIH HHS K22 AI127836NIAID NIH HHS R01 AI085515NIAID NIH HHS R01 AI095178NIAID NIH HHS R01 AI100527NIAID NIH HHS R01 AI132359NIAID NIH HHS R01 AI155425NIAID NIH HHS R01 AI168307NIAID NIH HHS R21 AI148904
6 · The paper itself

Abstract

Malaria, caused by

Indexed as

MalariaParasitesPlasmodiumAnimalsCaspasesDNA-Binding ProteinsHepatocytesHumansLiverAIM2 protein, humanCaspasesDNA-Binding ProteinsCaspase-1innate immunityliverMalaria

Identifiers

PMID36595704
PMCPMC9926219
OpenAlexW4313528656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.