Evidence map›Paper›PMID 36595676›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Burkitt lymphoma risk shows geographic and temporal associations with

Kelly Broen, Joey Dickens, Rob Trangucci, Martin D Ogwang, Constance N Tenge, Nestory Masalu, Steven J Reynolds, Esther Kawira, Patrick Kerchan, Pamela A Were and 14 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Subtyping Burkitt Lymphoma by DNA Methylation.Genes, chromosomes & cancer · 2025
    Article
  8. Article
  9. Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda.Metabolomics : Official journal of the Metabolomic Society · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kelly BroenDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-2220-4026
Joey DickensDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109.
Rob TrangucciDepartment of Statistics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-4592-718X
Martin D OgwangEMBLEM Study, St. Mary's Hospital, Lacor, Gulu.
Constance N TengeEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
Nestory MasaluEMBLEM Study, Bugando Medical Center, Mwanza, Tanzania.
Steven J ReynoldsDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-5403-2759
Esther KawiraEpidemiology of Burkitt Lymphoma in East-African Children and Minors (EMBLEM) Study, Shirati Health and Educational Foundation, Shirati, Tanzania.
Patrick KerchanAfrican Field Epidemiology Network, Kampala, Uganda.
Pamela A WereEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
Robert T KuremuEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.ORCID 0000-0001-7389-834X
Walter N WekesaEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
Tobias KinyeraEMBLEM Study, St. Mary's Hospital, Lacor, Gulu.
Isaac OtimEMBLEM Study, St. Mary's Hospital, Lacor, Gulu.
Ismail D LegasonAfrican Field Epidemiology Network, Kampala, Uganda.
Hadija NabalendeEMBLEM Study, St. Mary's Hospital, Lacor, Gulu.
Ian D BullerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-9477-8582
Leona W AyersDepartment of Pathology,The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-7261-260X
Kishor BhatiaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Robert J BiggarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
James J GoedertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Mark L WilsonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-2968-5181
Sam M MbulaiteyeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-8273-9831
Jon ZelnerDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-0708-2008

Funding

Cancer Risk in Human PopulationsZIACP010136 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$36.7M
Epidemiology and Natural History of Cancer-Associated VirusesZIACP010176 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MBULAITEYE, SAM M · 2009 to 2025
$33.7M
International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
NCI NIH HHS HHSN261201100007INCI NIH HHS HHSN261201100063C
6 · The paper itself

Abstract

Endemic Burkitt lymphoma (eBL) is a pediatric cancer coendemic with malaria in sub-Saharan Africa, suggesting an etiological link between them. However, previous cross-sectional studies of limited geographic areas have not found a convincing association. We used spatially detailed data from the Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) study to assess this relationship. EMBLEM is a case-control study of eBL from 2010 through 2016 in six regions of Kenya, Uganda, and Tanzania. To measure the intensity of exposure to the malaria parasite,

Indexed as

Burkitt LymphomaMalariaMalaria, FalciparumCase-Control StudiesCross-Sectional StudiesHumansKenyaPlasmodium falciparumTanzaniaUgandaEast Africaendemic Burkitt’s lymphoma (eBL)epidemiologynon-Hodgkin lymphomaPlasmodium falciparum malaria

Identifiers

PMID36595676
PMCPMC9926229

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.