Evidence map›Paper›PMID 36595653›Full record

ArticleACS biomaterials science & engineering2023

Degradable Biocompatible Porous Microtube Scaffold for Extended Donor Cell Survival and Activity.

Helen Nguyen, Chien-Chung Chen, Andreas Czosseck, Max M Chen, Thomashire A George, David J Lundy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Helen NguyenGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan.
Chien-Chung ChenGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan.
Andreas CzosseckGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan.
Max M ChenGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan.ORCID 0000-0002-1063-6710
Thomashire A GeorgeInternational Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan.
David J LundyGraduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei 110, Taiwan.ORCID 0000-0003-0848-3206
Taipei Medical University · TWTaipei Medical University Hospital · TWUniversity of Sierra Leone · SL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell therapy has significant therapeutic potential but is often limited by poor donor cell retention and viability at the host implantation site. Biomaterials can improve cell retention by providing cells with increased cell-cell and cell-matrix contacts and materials that allow three-dimensional cell culture to better recapitulate native cell morphology and function. In this study, we engineered a scaffold that allows for cell encapsulation and sustained three-dimensional cell culture. Since cell therapy is largely driven by paracrine secretions, the material was fabricated by electrospinning to have a large internal surface area, micrometer-thin walls, and nanoscale surface pores to allow for nutrient exchange without early cell permeation. The material is degradable, which allows for less invasive removal of the implant. Here, a biodegradable poly(lactic-

Indexed as

Lactic AcidPolyglycolic AcidAnimalsCell SurvivalHumansMicePolylactic Acid-Polyglycolic Acid CopolymerPorosityLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymerbiomaterial implantationcell culture scaffoldfibroblasthost response

Identifiers

PMID36595653
PMCPMC9930086
OpenAlexW4313489236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.