Evidence map›Paper›PMID 36595501›Full record

ArticlePloS one2023

Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection.

Daisuke Kitagawa, Taito Kitano, Madoka Furumori, Soma Suzuki, Yui Shintani, Hiroki Nishikawa, Rika Suzuki, Naohiro Yamamoto, Masayuki Onaka, Atsuko Nishiyama and 9 more

Abstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Daisuke KitagawaDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.ORCID 0000-0002-5352-8621
Taito KitanoJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.ORCID 0000-0003-0623-066X
Madoka FurumoriDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Soma SuzukiDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Yui ShintaniDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.
Hiroki NishikawaDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Rika SuzukiDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Naohiro YamamotoDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Masayuki OnakaDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Atsuko NishiyamaDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Takehito KasamatsuDepartment of Infectious Diseases, Nara Prefecture General Medical Center, Nara, Japan.
Naoyuki ShiraishiDepartment of Infectious Diseases, Nara Prefecture General Medical Center, Nara, Japan.
Yuki SuzukiDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Nara, Japan.
Akiyo NakanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Nara, Japan.ORCID 0000-0003-1379-384X
Ryuichi NakanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Nara, Japan.
Hisakazu YanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara, Nara, Japan.
Koichi MaedaDepartment of Infectious Diseases, Nara Prefecture General Medical Center, Nara, Japan.
Sayaka YoshidaDepartment of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Fumihiko NakamuraDepartment of Laboratory Medicine, Nara Prefecture General Medical Center, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the impact of the prolonged COVID-19 pandemic on outpatient antibiotic prescriptions for pediatric respiratory infections at an acute care hospital in Japan in order to direct future pediatric outpatient antibiotic stewardship. The impact of the COVID-19 pandemic and the FilmArray Respiratory Panel (RP) on outpatient antibiotic prescriptions was assessed from January 2019 to December 2021 using an interrupted time series analysis of children <20 years. The overall antimicrobial prescription rate decreased from 38.7% to 22.4% from the pre-pandemic period to the pandemic. The pandemic (relative risk [RR] level, 0.97 [0.58-1.61]; P = 0.90; RR slope, 1.05 [0.95-1.17] per month; P = 0.310) and FilmArray RP (RR level, 0.90 [0.46-1.75]; P = 0.75; RR slope, 0.95 [0.85-1.06] per month; P = 0.330) had no significant effect on the monthly antibiotic prescription rates. The COVID-19 pandemic was not significantly related to the antibiotic prescription rate, suggesting that it did not impact physicians' behavior toward antibiotic prescriptions. Replacing rapid antigen tests with the FilmArray RP introduced on December 1, 2020, did not affect the magnitude of the reduction in antibiotic prescription rate for pediatric respiratory infections.

Indexed as

COVID-19Respiratory Tract InfectionsAnti-Bacterial AgentsChildDrug PrescriptionsHumansMultiplex Polymerase Chain ReactionOutpatientsPractice Patterns, Physicians'Anti-Bacterial Agents

Identifiers

PMID36595501
PMCPMC9810151

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.