Evidence map›Paper›PMID 36595221›Full record

ArticleFEBS open bio2023

Mouse embryonic stem cell-derived motor neurons are susceptible to ferroptosis.

Alejandra M Martinez, Ahryun Kim, Cristina Aguilar Flores, Daoud F Rahman, Wan Seok Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Neuroferroptosis in health and diseases.Nature reviews. Neuroscience · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Alejandra M MartinezDepartment of Biological Sciences, St. John's University, New York City, New York, USA.
Ahryun KimDepartment of Biological Sciences, St. John's University, New York City, New York, USA.
Cristina Aguilar FloresDepartment of Biological Sciences, St. John's University, New York City, New York, USA.
Daoud F RahmanDepartment of Biological Sciences, St. John's University, New York City, New York, USA.
Wan Seok YangDepartment of Biological Sciences, St. John's University, New York City, New York, USA.ORCID 0000-0003-0017-3991
St. John's University · US

Funding

Determination of cell death pathways activated in ALSSC2NS104275 · NINDS · ST. JOHN'S UNIVERSITY · PI YANG, WAN S. · 2017 to 2019
$492k
NINDS NIH HHS SC2 NS104275
6 · The paper itself

Abstract

Ferroptosis is a regulated form of cell death driven by the lethal accumulation of lipid peroxides in cell membranes. Several regulators of ferroptosis have been identified using cancer cell lines. However, the cellular pathways of ferroptosis in neurons remain poorly characterized. In this study, we used a mouse embryonic stem cell-derived motor neuron model to investigate how motor neurons respond to ferroptosis inducers. Pharmacological and genetic inhibition of glutathione peroxidase 4 (GPx4) induced ferroptosis in motor neurons, while system x

Indexed as

FerroptosisAnimalsCell DeathGlutathione PeroxidaseMiceMotor NeuronsMouse Embryonic Stem CellsGlutathione PeroxidaseALScalciumferroptosisglutathione peroxidase 4neuronstem cells

Identifiers

PMID36595221
PMCPMC9989922
OpenAlexW4313453866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.