Evidence map›Paper›PMID 36595064›Full record

Trial reportClinical oral investigations2023

Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial.

Aysan Lektemur Alpan, Gizem Torumtay Cin

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07458685 (Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07458685 nacompletednot on this map

Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversity of MilanRan2022 to 2025Enrolled20ConditionsPalatal Donor Site Wound Healing, Palatal WoundArmsTest - xHyA, Negative control
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  19. Biomaterials strategy for promoting palatal wound healing.Frontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aysan Lektemur AlpanDepartment of Periodontology, Faculty of Dentistry, Pamukkale University, Kınıklı Campus, 20160, Denizli, Turkey. ysnlpn@gmail.com.ORCID http://orcid.org/0000-0002-5939-4783
Gizem Torumtay CinDepartment of Periodontology, Faculty of Dentistry, Pamukkale University, Kınıklı Campus, 20160, Denizli, Turkey.ORCID http://orcid.org/0000-0002-5362-4146
Pamukkale University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to evaluate the effects of topical hyaluronic acid (HA), hypochlorous acid (HOCl), and flurbiprofen on postoperative morbidity of palatal donor sites after free gingival graft (FGG) surgery. MATERIALS AND

methodsSixty patients requiring FGG were randomly assigned into four groups: control, HA gel (600 mg/100 g high molecular weight hyaluronic acid), HOCl spray (170-200 ppm, ph7.1), flurbiprofen spray (0.075gr flurbiprofen). Topical agents were applied for 14 days, according to groups. Patients were followed for 28 days. Palatal healing was assessed with the Laundry wound healing index (WHI). Complete epithelization (CE) was evaluated with photographs and H

resultsHA provided better WHI values on the 7

conclusionsHA exhibits a positive impact on the epithelization of palatal wound healing and color matching. HOCl and flurbiprofen provided less pain; however, they might have negative effects on palatal wound healing. CLINICAL RELEVANCE: As a result of obtaining free gingival grafts from palatal tissue for mucogingival surgical procedures, secondary wound healing of the donor area occurs. This wound in the palatal region can cause discomfort and pain every time patients use their mouths. The use of HA can reduce postoperative complications by accelerating wound healing and reducing pain. The topical use of flurbiprofen and HOCl can reduce patients' pain.

Indexed as

FlurbiprofenHyaluronic AcidGingivaHumansHydrogen PeroxideHypochlorous AcidMorbidityPalatePostoperative PainFlurbiprofenHyaluronic AcidHydrogen PeroxideHypochlorous AcidOperativePainPlastic periodontal surgeryPostoperative complicationsSurgical proceduresWound healing

Identifiers

PMID36595064
PMCPMC9808727
OpenAlexW4313454260

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.