Evidence map›Paper›PMID 36594836›Full record

ArticleRadiology2023

Differences in Molecular Subtype Reference Standards Impact AI-based Breast Cancer Classification with Dynamic Contrast-enhanced MRI.

Yu Ji, Heather M Whitney, Hui Li, Peifang Liu, Maryellen L Giger, Xuening Zhang

Abstract read
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  2. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yu JiFrom the Department of Radiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Rd, Hexi District, Tianjin, China 300211 (Y.J., X.Z.); National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (Y.J., P.L.); Department of Radiology, The University of Chicago, Chicago, Ill (H.M.W., H.L., M.L.G.); and Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.).ORCID 0000-0002-3741-5627
Heather M WhitneyFrom the Department of Radiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Rd, Hexi District, Tianjin, China 300211 (Y.J., X.Z.); National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (Y.J., P.L.); Department of Radiology, The University of Chicago, Chicago, Ill (H.M.W., H.L., M.L.G.); and Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.).ORCID 0000-0002-7258-1102
Hui LiFrom the Department of Radiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Rd, Hexi District, Tianjin, China 300211 (Y.J., X.Z.); National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (Y.J., P.L.); Department of Radiology, The University of Chicago, Chicago, Ill (H.M.W., H.L., M.L.G.); and Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.).ORCID 0000-0003-3139-2898
Peifang LiuFrom the Department of Radiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Rd, Hexi District, Tianjin, China 300211 (Y.J., X.Z.); National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (Y.J., P.L.); Department of Radiology, The University of Chicago, Chicago, Ill (H.M.W., H.L., M.L.G.); and Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.).ORCID 0000-0002-7333-0110
Maryellen L GigerFrom the Department of Radiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Rd, Hexi District, Tianjin, China 300211 (Y.J., X.Z.); National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (Y.J., P.L.); Department of Radiology, The University of Chicago, Chicago, Ill (H.M.W., H.L., M.L.G.); and Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.).ORCID 0000-0001-5482-9728
Xuening ZhangFrom the Department of Radiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Rd, Hexi District, Tianjin, China 300211 (Y.J., X.Z.); National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China (Y.J., P.L.); Department of Radiology, The University of Chicago, Chicago, Ill (H.M.W., H.L., M.L.G.); and Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.).ORCID 0000-0002-4621-5731

Funding

RADX TECH - CERES NANOSCIENCE INC NANOTRAP PARTICLE MANUFACTURING75N92020C00021 · NHLBI · CERES NANOSCIENCES, LLLP · PI DUNLAP, ROSS · 2021 to 2021
$4.0M
Lesion Composition and Quantitative Imaging Analysis on Breast Cancer DiagnosisR01CA257652 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GIGER, MARYELLEN L., SHEPHERD, JOHN ALAN · 2021 to 2025
$3.2M
Integrative molecular and imaging approaches for risk of subtype specific breastU01CA189240 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI BEDROSIAN, ISABELLE, EL-ZEIN, RANDA A · 2015 to 2019
$2.9M
Quantitative Image Analysis for Assessing Response to Breast Cancer TherapyU01CA195564 · NCI · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2015 to 2019
$2.5M
Assessment of Repeatability and Robustness of Radiomics in Breast Cancer ImagingR15CA227948 · NCI · WHEATON COLLEGE · PI WHITNEY, HEATHER M · 2019 to 2019
$397k
Protected Radiomics Analysis Commons for Deep Learning in Biomedical DiscoveryS10OD025081 · OD · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2018 to 2018
$339k
NCI NIH HHS R01 CA257652NCI NIH HHS R15 CA227948NCI NIH HHS U01 CA189240NCI NIH HHS U01 CA195564NHLBI NIH HHS 75N92020C00008NHLBI NIH HHS 75N92020C00021NIH HHS S10 OD025081
6 · The paper itself

Abstract

Background Breast cancer tumors can be identified as different luminal molecular subtypes depending on either immunohistochemical (IHC) staining or St Gallen criteria that includes Ki-67. Purpose To characterize molecular subtypes and understand the impact of disagreement among IHC and St Gallen molecular subtype reference standards on artificial intelligence classification of luminal A and luminal B tumors with use of radiomic features extracted from dynamic contrast-enhanced (DCE) MRI scans. Materials and Methods In this retrospective study, 28 radiomic features previously extracted from DCE-MRI scans of breast tumors imaged between February 2015 and October 2017 were examined in the following groups:

Indexed as

Breast NeoplasmsArtificial IntelligenceFemaleHumansMagnetic Resonance ImagingMiddle AgedReference StandardsRetrospective Studies

Identifiers

PMID36594836
PMCPMC10068887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.