ArticleeLife2023
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- RNA-Based Therapeutics in Genetic Neurodevelopmental Disorders: Bridging Molecular Genetics and Precision Medicine.International journal of molecular sciences · 2026Review
- Fatty-acid-based antimiR-23b delivery in the DMSXL model: A potential therapeutic strategy for brain dysfunction in myotonic dystrophy type 1.Cell reports. Medicine · 2026Article
- Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Periodic and aperiodic contributions to EEG delta power are translatable and complementary Angelman syndrome biomarkers.Communications medicine · 2026Article
- A dual-reporter mouse for therapeutic discovery in Angelman syndrome.JCI insight · 2026Article
- Crossing the finish line towards a disease-modifying treatment for Angelman syndrome.Journal of neurodevelopmental disorders · 2026Review
- Extracellular vesicle dysfunction contributes to synaptic and cognitive deficits in a mouse model of Angelman syndrome.Progress in neurobiology · 2026Article
- RNAi-Induced Expression of Paternal UBE3A.Genes · 2026Article
- Extracellular Vesicles in Angelman Syndrome: Expanding UBE3A Role beyond a Cell Autonomous Mechanism.Journal of experimental neurology · 2026Article
- Targeting Cathepsin B-mediated pyroptosis in fibroblasts alleviate ultraviolet-induced skin inflammation and injury.Cell communication and signaling : CCS · 2025Article
- Article
- Courtship and distress ultrasonic vocalizations are altered in a mouse model of Angelman syndrome.Journal of neurodevelopmental disorders · 2025Article
- AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription.Communications biology · 2025Article
- Article
- Monogenic Epilepsies in Adult Epilepsy Clinics and Gene-Driven Approaches to Treatment.Current neurology and neuroscience reports · 2025Review
- A human Angelman Syndrome class II pluripotent stem cell line with fluorescent paternalFrontiers in cell and developmental biology · 2025Article
- RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction.Frontiers in molecular biosciences · 2025Review
- A clinical-translational review of sleep problems in neurodevelopmental disabilities.Journal of neurodevelopmental disorders · 2024Review
- Modelling phenotypes, variants and pathomechanisms of syndromic diseases in different systems.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2024Article
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey.Frontiers in neuroanatomy · 2024Article
Corrections and comments
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- Erratum issued
Authors and funding
15 authors at 2 institutions in 1 country.
Dongwon Lee *Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Wu Chen *Department of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0002-7400-0519
Heet Naresh Kaku *Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Xinming Zhuo *Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Eugene S ChaoDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Armand SorianoIonis Pharmaceuticals, Carlsbad, United States.
Allen KuncheriaDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Stephanie FloresDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Joo Hyun KimDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Armando RiveraDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0001-7076-8566
Frank RigoIonis Pharmaceuticals, Carlsbad, United States.
Paymaan Jafar-NejadIonis Pharmaceuticals, Carlsbad, United States.
Arthur L BeaudetDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Matthew S CaudillDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.
Mingshan XueDepartment of Neuroscience, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0003-1463-8884
Baylor College of Medicine · USIonis Pharmaceuticals (United States) · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9MActivity-Dependent Mechanisms Regulating Synaptic Excitation and Inhibition in Neural CircuitsR01MH117089 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI XUE, MINGSHAN · 2018 to 2022
$2.0MSynaptic Dysfunction of Neural Circuits in Neurodevelopmental DisordersR01NS100893 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI XUE, MINGSHAN · 2017 to 2021
$1.7MNCI NIH HHS P30 CA125123NICHD NIH HHS P50 HD103555NIMH NIH HHS R01 MH117089NIMH NIH HHS R01MH117089NINDS NIH HHS R01 NS100893NINDS NIH HHS R01NS100893
Abstract
PubMed holds no abstract for this paper.
Indexed as
Angelman SyndromeAnimalsBrainDisease Models, AnimalMiceMice, KnockoutOligonucleotides, AntisenseSleepUbiquitin-Protein LigasesOligonucleotides, AntisenseUbiquitin-Protein LigasesASOEEGmouseneurodevelopmental disorderneuroscienceRNA therapeutics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.