Evidence map›Paper›PMID 36594611›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor-Specific and Ferroptosis-Augmented Sonodynamic Therapy.

Shanshan Zhang, Shujun Xia, Liang Chen, Yu Chen, Jianqiao Zhou

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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  17. Preparation of LaFrontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shanshan ZhangDepartment of Ultrasound Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, P. R. China.
Shujun XiaDepartment of Ultrasound Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, P. R. China.
Liang ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.ORCID 0000-0002-1437-4308
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.ORCID 0000-0002-8206-3325
Jianqiao ZhouDepartment of Ultrasound Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, P. R. China.

Funding

Basic Research Program of Shanghai Municipal Government 21JC1406002National Natural Science Foundation of China 52072393National Natural Science Foundation of China 52102350Qingnian Yingcai Qihang Plan of Shanghai UniversityShanghai Science and Technology 21010500100Shanghai Science and Technology 22140901700Shanghai Science and Technology 22142202200Shanghai Science and Technology 22DZ2204700Shanghai Science and Technology Committee Rising-Star Program 21QA1403100
6 · The paper itself

Abstract

Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs-based nanosensitizers with uniform nanoscale morphology and tumor-specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls are synthesized in a controlled manner and engineered as activatable nanosensitizers with tumor-specific sonodynamic activity. High crystallinity ensures an ordered porous structure of COF nanobowls for the efficient loading of the small-molecule sonosensitizer rose bengal (RB). To circumvent non-specific damage to normal tissues, the sonosensitization effect is specifically inhibited by the in situ growth of manganese oxide (MnO

Indexed as

FerroptosisMetal-Organic FrameworksNeoplasmsHumansReactive Oxygen SpeciesMetal-Organic FrameworksReactive Oxygen Speciesactivatable therapybiomedicinecovalent organic frameworksferroptosissonodynamic therapy

Identifiers

PMID36594611
PMCPMC9951320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.