Evidence map›Paper›PMID 36594085›Full record

ArticleInternational journal of biological sciences2023

The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis

Yeye Kuang, Zhanglian He, Lili Li, Chan Wang, Xiaoqing Cheng, Qinglan Shi, Guoxiang Fu, Jianming Ying, Qian Tao, Xiaotong Hu

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yeye KuangBiomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Zhanglian HeBiomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Lili LiCancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
Chan WangBiomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Xiaoqing ChengDepartment of Pathology, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Qinglan ShiBiomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Guoxiang FuDepartment of Pathology, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Jianming YingCancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
Qian TaoCancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
Xiaotong HuBiomedical Research Center, Sir Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Chinese University of Hong Kong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic disruption of tumor suppressor genes, particularly aberrant CpG methylation, plays a crucial role in gastric cancer (GC) pathogenesis. Through CpG methylome and expression profiling, a developmental transcription factor

Indexed as

CisplatinStomach NeoplasmsApoptosisCarcinogenesisCell Line, TumorEndoplasmic Reticulum StressGene Expression RegulationHumansTranscription Factor CHOPCisplatinTranscription Factor CHOPapoptosisBAK.CHOPgastric cancerHAND1methylationtumor suppressor gene

Identifiers

PMID36594085
PMCPMC9760445
OpenAlexW4309750814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.