Evidence map›Paper›PMID 36594083›Full record

ArticleInternational journal of biological sciences2023

Tendon Cells Root Into (Instead of Attach to) Humeral Bone Head via Fibrocartilage-Enthesis.

Zheng Wang, Chi Ma, Diane Chen, Caitlin Haslett, Chunmei Xu, Changchun Dong, Xiaofang Wang, Minghao Zheng, Yan Jing, Jian Q Feng

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. [Application of Kartogenin in cartilage tissue engineering].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. The effects of dietary loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zheng WangDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA.
Chi MaDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 75219, USA.
Diane ChenDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA.
Caitlin HaslettDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA.
Chunmei XuDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA.
Changchun DongDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA.
Xiaofang WangDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA.
Minghao ZhengCentre for Orthopaedic Research, Medical School, The University of Western Australia, Nedlands, WA, Australia.
Yan JingDepartment of Orthodontics, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Jian Q FengDental School and Oral Health Centre, The University of Western Australia, Nedlands, 6009 Australia.
Texas A&M University · USUniversity of Western Australia · AU

Funding

Novel roles of tendon during TMJ postnatal growth and onset of diseasesR01DE028547 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Yan Jing · 2022 to 2026
$1.4M
Multiphoton Laser Scanning MicroscopeS10OD028735 · OD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI BENSON, M. DOUGLAS · 2021 to 2021
$829k
To define the novel roles of endochondrogenesis in mandible formation and trauma repairK08DE028593 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI JING, YAN · 2021 to 2025
$529k
The novel roles of tendon in TMJ condyle formation and remodelingR03DE029541 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI JING, YAN · 2020 to 2021
$300k
NIDCR NIH HHS K08 DE028593NIDCR NIH HHS R01 DE028547NIDCR NIH HHS R03 DE029541NIH HHS S10 OD028735
6 · The paper itself

Abstract

Large joints are composed of two closely linked cartilages: articular cartilage (AC; rich in type II collagen, a well-studied tissue) and fibrocartilaginous enthesis (FE; rich in type I collagen, common disorder sites of enthesopathy and sporting injuries, although receiving little attention). For many years, both cartilages were thought to be formed by chondrocytes, whereas tendon, which attaches to the humeral bone head, is primarily considered as a completely different connective tissue. In this study, we raised an unconventional hypothesis: tendon cells directly form FE via cell transdifferentiation

Indexed as

EnthesopathyAnimalsFibrocartilageHumerusMiceTamoxifenTendonsTamoxifenCell lineage tracingFibrocartilaginous enthesisScxTendon cell

Identifiers

PMID36594083
PMCPMC9760439
OpenAlexW4309750502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.