ArticleNature biotechnology2023
Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment.
Article in Nature biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors of local control in adrenal metastases treated by stereotactic body radiation therapy - a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026Review
- Clinical Pilot Study of Ionizing Radiation Acoustic Imaging for Real-Time Visualization of Radiation Therapy Dose Delivery in Cancer Patients.International journal of radiation oncology, biology, physics · 2026Article
- Shape-optimized Model-based Reconstruction Algorithm for Radiacoustic Imaging.Applied physics letters · 2026Article
- Limited-view signal recovery with frequency-aware denoising diffusion and geometry-integrated masked autoencoders for X-ray acoustic computed tomography.Photoacoustics · 2026Article
- Fiber-Tip Surface-Micromachined Optical Ultrasound Transducer (SMOUT) Probe for Acoustic Detection Induced by Ultrahigh Dose Rate (UHDR) Electron Beam.IEEE sensors journal · 2026Article
- Ionizing radiation acoustic beam localization: one step towards "proton surgery".medRxiv : the preprint server for health sciences · 2026Article
- A Physics-Informed Neural Network forResearch square · 2026Article
- Seeing the invisible: In vivo dosimetry in radiotherapy with radiacoustic IMAGING.Medical physics · 2025Review
- Application of respiratory motion management technology for patients with lung cancer treated with stereotactic body radiotherapy (Review).Oncology letters · 2025Review
- Towards quantitative ionizing radiation acoustic imaging (iRAI) for radiation dose measurement: Validation from simulations to experiments.Medical physics · 2025Article
- Ionizing radiation acoustic and ultrasound dual-modality imaging for visualization of dose on anatomical structures during radiotherapy.Photoacoustics · 2025Article
- The Biophysics of Flash Radiotherapy: Tools for Measuring Tumor and Normal Tissues Microenvironment.Antioxidants (Basel, Switzerland) · 2025Review
- Real-Time Dose-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2025Review
- Thermoacoustic range verification during conventional dose rate delivery by a synchrocyclotron.Medical physics · 2025Article
- A novel SGRT system for real-time optical surface tracking or guidance.Journal of applied clinical medical physics · 2025Article
- Artificial intelligence in four-dimensional imaging for motion management in radiation therapy.Artificial intelligence review · 2025Article
- X-ray-induced acoustic computed tomography: 3D X-ray absorption imaging from a single view.Science advances · 2024Article
- Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging.Nature communications · 2024Article
- 4DPhysics in medicine and biology · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation's interactions with tissues during radiation therapy, providing real-time, adaptive feedback for cancer treatments. We describe an iRAI volumetric imaging system that enables mapping of the three-dimensional (3D) radiation dose distribution in a complex clinical radiotherapy treatment. The method relies on a two-dimensional matrix array transducer and a matching multi-channel preamplifier board. The feasibility of imaging temporal 3D dose accumulation was first validated in a tissue-mimicking phantom. Next, semiquantitative iRAI relative dose measurements were verified in vivo in a rabbit model. Finally, real-time visualization of the 3D radiation dose delivered to a patient with liver metastases was accomplished with a clinical linear accelerator. These studies demonstrate the potential of iRAI to monitor and quantify the 3D radiation dose deposition during treatment, potentially improving radiotherapy treatment efficacy using real-time adaptive treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.