Evidence map›Paper›PMID 36593404›Full record

ArticleNature biotechnology2023

A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.

Tongrui Qian, Huan Wang, Peng Wang, Lan Geng, Long Mei, Takuya Osakada, Lei Wang, Yan Tang, Alan Kania, Valery Grinevich and 4 more

Open access · greenAbstract read
In one paragraph

Article in Nature biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
40.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
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  8. Astrocytes mediate a positive feedback loop for oxytocin.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Review
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Tongrui Qian *State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID 0000-0002-0329-4687
Huan Wang *State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Peng Wang *Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-3047-1666
Lan GengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Long MeiNeuroscience Institute, Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Takuya OsakadaNeuroscience Institute, Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Lei WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yan TangCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Alan KaniaDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-3823-6196
Valery GrinevichDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Ron StoopCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Dayu LinNeuroscience Institute, Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-2006-0791
Minmin LuoNational Institute of Biological Sciences (NIBS), Beijing, China.ORCID 0000-0003-3535-6624
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China. yulongli@pku.edu.cn.ORCID 0000-0002-9166-9919
Peking University · CNNew York University · USHeidelberg University · DEUniversity of Lausanne · CHCapital Medical University · CNMcGovern Institute for Brain Research · USNational Institute of Biological Sciences, Beijing · CN

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Christopher Mar · 2018 to 2026
$36.4M
Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
Novel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3M
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
Dissecting the neural circuits of maternal behaviorsR01HD092596 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2018 to 2022
$2.4M
Novel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2M
NICHD NIH HHS R01 HD092596NIMH NIH HHS R01 MH101377NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS120824NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Oxytocin (OT), a peptide hormone and neuromodulator, is involved in diverse physiological and pathophysiological processes in the central nervous system and the periphery. However, the regulation and functional sequences of spatial OT release in the brain remain poorly understood. We describe a genetically encoded G-protein-coupled receptor activation-based (GRAB) OT sensor called GRAB

Indexed as

NeuronsOxytocinAnimalsBrainCentral Nervous SystemMaleMiceSignal TransductionOxytocin

Identifiers

PMID36593404
PMCPMC11182738
OpenAlexW4313454408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.