Evidence map›Paper›PMID 36593401›Full record

ArticleNature biotechnology2023

High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.

Peter M Bruno, Richard T Timms, Nouran S Abdelfattah, Yumei Leng, Felipe J N Lelis, Duane R Wesemann, Xu G Yu, Stephen J Elledge

Open access · bronzeAbstract read
In one paragraph

Article in Nature biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  7. Article
  8. Review
  9. Article
  10. High-throughput screening for class I peptide MHC binding via yeast surface display.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Specific Instability of HLA-A*03:01 Expression in HEK-293 Cells.International journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Computational modeling of human genetic variants in mice.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Peter M BrunoDepartment of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-3383-0118
Richard T TimmsDepartment of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-7275-597X
Nouran S AbdelfattahDepartment of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.
Yumei LengDepartment of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.
Felipe J N LelisDepartment of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Duane R WesemannDepartment of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6690-944X
Xu G YuRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Stephen J ElledgeDepartment of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA. selledge@genetics.med.harvard.edu.ORCID 0000-0001-7923-6283
Brigham and Women's Hospital · US

Funding

Elucidating Germinal Center-Mediated Antibody EvolutionR01AI139538 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2019 to 2022
$2.4M
Analysis of the Mammalian DNA Damage ResponseR01CA234600 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELLEDGE, STEPHEN J · 2019 to 2023
$2.0M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA234600NIAID NIH HHS R01 AI139538Wellcome Trust 201387Wellcome Trust 201387/Z/16/Z
6 · The paper itself

Abstract

Identification of CD8

Indexed as

CysteineHistocompatibility Antigens Class IEpitopes, T-LymphocyteLigandsPeptidesProtein BindingCysteineEpitopes, T-LymphocyteHistocompatibility Antigens Class ILigandsPeptides

Identifiers

PMID36593401
PMCPMC10314971
OpenAlexW4313453360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.