Evidence map›Paper›PMID 36593337›Full record

ArticleEuropean journal of epidemiology2023

Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts.

Kala Visvanathan, Alison M Mondul, Anne Zeleniuch-Jacquotte, Molin Wang, Mitchell H Gail, Shiaw-Shyuan Yaun, Stephanie J Weinstein, Marjorie L McCullough, A Heather Eliassen, Nancy R Cook and 48 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Micronutrient Status and Breast Cancer: A Narrative Review.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. The impact of vitamin D on cancer: A mini review.The Journal of steroid biochemistry and molecular biology · 2023
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors at 20 institutions in 6 countries.

Kala Visvanathan *Departments of Epidemiology and Oncology, Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Center, Baltimore, MD, USA.
Alison M Mondul *Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Anne Zeleniuch-Jacquotte *Departments of Population Health and Environmental Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Molin WangDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mitchell H GailDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Shiaw-Shyuan YaunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Marjorie L McCulloughDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nancy R CookDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Claudia AgnoliEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Martin AlmquistDepartment of Surgery, Skane University Hospital, Lund, Sweden.
Amanda BlackDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Chu ChenDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Yu ChenDepartments of Population Health and Environmental Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Tess ClendenenDepartments of Population Health and Environmental Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Laure DossusNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Gretchen L GierachDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Edward L GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Gary E GoodmanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Marc T GoodmanCancer Prevention and Control Research Program, Cedars Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.
Pascal GuénelCenter for Research in Epidemiology and Population Health (CESP), French National Institute of Health and Medical Research (INSERM), University Paris-Saclay, Villejuif, France.
Göran HallmansDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Susan E HankinsonDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Ronald L HorstHeartland Assays, LLC, Ames, IA, USA.
Tao HouDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Corrine E JoshuDepartments of Epidemiology and Oncology, Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Center, Baltimore, MD, USA.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Vittorio KroghEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marina KvaskoffCenter for Research in Epidemiology and Population Health (CESP), French National Institute of Health and Medical Research (INSERM), University Paris-Saclay, Villejuif, France.
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Yahya Mahamat-SalehCenter for Research in Epidemiology and Population Health (CESP), French National Institute of Health and Medical Research (INSERM), University Paris-Saclay, Villejuif, France.
Johan MalmDepartment of Translational Medicine, Lund University, Malmö, Sweden.
Jonas ManjerDepartment of Surgery, Skane University Hospital, Lund University, Malmö, Sweden.
Gertraud MaskarinecCancer Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Amy E MillenDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA.
Toqir K MukhtarDepartment of Primary Care and Public Health, Imperial College, London, UK.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Trude E RobsahmCancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Sabina SieriEpidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
Malin SundDepartment of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Cynthia A ThomsonDepartment of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona and University of Arizona Cancer Center, Tucson, AZ, USA.
Giske UrsinCancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA.
Ying WangDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Lynne R WilkensPopulation Sciences in the Pacific, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Yujie WuDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Emilie ZoltickDepartment of Population Medicine, Harvard Medical School, Boston, MA, USA.
Walter C WillettDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Stephanie A Smith-Warner *Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Regina G Ziegler *Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. regina.ziegler@nih.gov.ORCID http://orcid.org/0000-0002-5100-9852
Harvard University · USNational Institutes of Health · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USInserm · FRInstitute of Cancer Research · GBNew York University · USAmerican Cancer Society · USJohns Hopkins University · USLund University · SEUmeå University · SEUniversity at Buffalo, State University of New York · USUniversity of Hawaiʻi at Mānoa · USCancer Registry of Norway · NOCedars-Sinai Medical Center · USCentre international de recherche sur le cancer · FREmory University · USGerman Cancer Research Center · DEQueen's University Belfast · GBSkåne University Hospital · SE

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
PLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9M
Variation in Receptor Tyrosine Kinases and Breast Cancer RiskP50CA089393 · NCI · DANA-FARBER CANCER INSTITUTE · PI WINER, ERIC P · 2000 to 2009
$28.8M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA089393NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA152071NCI NIH HHS R03 CA183016NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA086308NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA176726NCI NIH HHS U01 CA182913NCI NIH HHS U01 CA182934NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA182913NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIA NIH HHS U01 AG018033NIEHS NIH HHS P30 ES000260World Health Organization 001
6 · The paper itself

Abstract

Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42-68) years at blood collection and 63 (49-75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, calibrated to this assay to permit using a common metric. Study-specific relative risks (RRs) for season-standardized 25(OH)D concentrations were estimated by conditional logistic regression and combined by random-effects models. Circulating 25(OH)D increased from a median of 22.6 nmol/L in consortium-wide decile 1 to 93.2 nmol/L in decile 10. Breast cancer risk in each decile was not statistically significantly different from risk in decile 5 in models adjusted for breast cancer risk factors, and no trend was apparent (P-trend = 0.64). Compared to women with sufficient 25(OH)D based on Institute of Medicine guidelines (50- < 62.5 nmol/L), RRs were not statistically significantly different at either low concentrations (< 20 nmol/L, 3% of controls) or high concentrations (100- < 125 nmol/L, 3% of controls; ≥ 125 nmol/L, 0.7% of controls). RR per 25 nmol/L increase in 25(OH)D was 0.99 [95% confidence intervaI (CI) 0.95-1.03]. Associations remained null across subgroups, including those defined by body mass index, physical activity, latitude, and season of blood collection. Although none of the associations by tumor characteristics reached statistical significance, suggestive inverse associations were seen for distant and triple negative tumors. Circulating 25(OH)D, comparably measured in 17 international cohorts and season-standardized, was not related to subsequent incidence of invasive breast cancer over a broad range in vitamin D status.

Indexed as

Breast NeoplasmsVitamin D DeficiencyCalcifediolFemaleHumansProspective StudiesRisk FactorsVitamin DCalcifediolVitamin D25-Hydroxyvitamin DBiomarkerBreast cancerCalibrationPooled analysisProspective cohort studyVitamin D

Identifiers

PMID36593337
PMCPMC10039648
OpenAlexW4313454758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.