Evidence map›Paper›PMID 36593284›Full record

ArticleScientific reports2023

A deep learning framework assisted echocardiography with diagnosis, lesion localization, phenogrouping heterogeneous disease, and anomaly detection.

Bohan Liu, Hao Chang, Dong Yang, Feifei Yang, Qiushuang Wang, Yujiao Deng, Lijun Li, Wenqing Lv, Bo Zhang, Liheng Yu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Bohan Liu *Medical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Hao Chang *Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, 06510, USA.
Dong YangKey Laboratory of Growth Regulation and Translation Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, 310024, China.
Feifei YangMedical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Qiushuang WangMedical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Yujiao DengMedical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Lijun LiDepartment of Cardiology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
Wenqing LvDepartment of Cardiology, Beijing Tongren Hospital, Beijing, 100176, China.
Bo ZhangDepartment of Ultrasound, Chinese PLA 923 Hospital, Nanning, 530021, China.
Liheng YuMedical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Daniel BurkhoffMedical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Kunlun HeMedical Big Data Research Center, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. kunlunhe@plagh.org.
Chinese PLA General Hospital · CN303 Hospital of People's Liberation Army · CNBeijing Tongren Hospital · CNHoward Hughes Medical Institute · USWestlake University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echocardiography is the first-line diagnostic technique for heart diseases. Although artificial intelligence techniques have made great improvements in the analysis of echocardiography, the major limitations remain to be the built neural networks are normally adapted to a few diseases and specific equipment. Here, we present an end-to-end deep learning framework named AIEchoDx that differentiates four common cardiovascular diseases (Atrial Septal Defect, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, prior Myocardial Infarction) from normal subjects with performance comparable to that of consensus of three senior cardiologists in AUCs (99.50% vs 99.26%, 98.75% vs 92.75%, 99.57% vs 97.21%, 98.52% vs 84.20%, and 98.70% vs 89.41%), respectively. Meanwhile, AIEchoDx accurately recognizes critical lesion regions of interest along with each disease by visualizing the decision-making process. Furthermore, our analysis indicates that heterogeneous diseases, like dilated cardiomyopathy, could be classified into two phenogroups with distinct clinical characteristics. Finally, AIEchoDx performs efficiently as an anomaly detection tool when applying handheld device-produced videos. Together, AIEchoDx provides a potential diagnostic assistant tool in either cart-based echocardiography equipment or handheld echocardiography device for primary and point-of-care medical personnel with high diagnostic performance, and the application of lesion region identification and heterogeneous disease phenogrouping, which may broaden the application of artificial intelligence in echocardiography.

Indexed as

Cardiomyopathy, DilatedCardiomyopathy, HypertrophicDeep LearningHeart DiseasesArtificial IntelligenceEchocardiographyHumans

Identifiers

PMID36593284
PMCPMC9807607
OpenAlexW4313477998

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.