Evidence map›Paper›PMID 36593275›Full record

ArticleNature chemical biology2023

Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex.

Hua Li, Digantkumar Chapla, Robert A Amos, Annapoorani Ramiah, Kelley W Moremen, Huilin Li

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  7. Review
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  11. The Intersection of Glycosylation and Ferroptosis in Cancer.Antioxidants (Basel, Switzerland) · 2025
    Review
  12. Article
  13. World journal of gastroenterology · 2025
    Article
  14. Structural glycobiology - from enzymes to organelles.Biochemical Society transactions · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hua Li *Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.
Digantkumar Chapla *Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Robert A AmosComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Annapoorani RamiahComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Kelley W MoremenComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA. moremen@uga.edu.ORCID http://orcid.org/0000-0003-1768-582X
Huilin LiDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA. huilin.Li@vai.org.ORCID http://orcid.org/0000-0001-8085-8928
University of Georgia · USVan Andel Institute · US

Funding

TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
The structure and function of eukaryotic protein glycosylation enzymesR01CA231466 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2018 to 2026
$4.0M
Origin of N-Glycan Site-Specific HeterogeneityR01GM130915 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, MOREMEN, KELLEY W. · 2019 to 2022
$3.4M
Molecular mechanisms for sorting lysosomal proteinsR01NS127292 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2022 to 2026
$2.4M
NCI NIH HHS R01 CA231466NIGMS NIH HHS P41 GM103390NIGMS NIH HHS R01 GM130915NIGMS NIH HHS R24 GM137782NINDS NIH HHS R01 NS127292
6 · The paper itself

Abstract

Heparan sulfate (HS) proteoglycans are extended (-GlcAβ1,4GlcNAcα1,4-)

Indexed as

Heparan SulfateProteinsAnimalsGlycosyltransferasesHumansMammalsN-AcetylglucosaminyltransferasesGlycosyltransferasesHeparan SulfateN-AcetylglucosaminyltransferasesProteins

Identifiers

PMID36593275
PMCPMC10160006
OpenAlexW4313454623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.