ArticleLight, science & applications2023
Non-invasive photoacoustic computed tomography of rat heart anatomy and function.
Article in Light, science & applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mapping blood vessels and oxygenation throughout the whole mouse brain with dual-frequency fiber-array photoacoustic computed tomography.Light, science & applications · 2026Article
- Robust hybrid feature-driven on-the-fly mapping enables freehand 3D panoramic photoacoustic angiography.Light, science & applications · 2026Article
- Three-dimensional aperture-driven photoacoustic tomography (3D-ADPAT).Science advances · 2026Article
- Multimodal deep learning with missing data robustness for enhanced early diagnosis of coronary artery disease using CCTA, clinical, and ECG data.BMC medical informatics and decision making · 2026Article
- Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT).Nature communications · 2025Article
- Review of Pulsation Signal Detection and Applications in Dynamic Photoacoustic Imaging.Biosensors · 2025Review
- Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles.Materials today. Bio · 2025Article
- Ischemic Myocardium Targeting Peptide-Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction.Advanced healthcare materials · 2025Article
- Optical theranostics in ischemic heart disease: from molecular insights to clinical translation.Theranostics · 2025Review
- Emerging Photoacoustic Imaging Techniques for Peripheral Arterial Disease.Current treatment options in cardiovascular medicine · 2025Review
- Review
- Perspectives on endoscopic functional photoacoustic microscopy.Applied physics letters · 2024Article
- Ultrafast photoacoustic cavitation pumped by picosecond laser for high-efficient and long-term shockwave theranostics.Photoacoustics · 2023Article
- Article
- Photoacoustic tomography reveals structural and functional cardiac images of animal models.Light, science & applications · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Complementary to mainstream cardiac imaging modalities for preclinical research, photoacoustic computed tomography (PACT) can provide functional optical contrast with high imaging speed and resolution. However, PACT has not been demonstrated to reveal the dynamics of whole cardiac anatomy or vascular system without surgical procedure (thoracotomy) for tissue penetration. Here, we achieved non-invasive imaging of rat hearts using the recently developed three-dimensional PACT (3D-PACT) platform, demonstrating the regulated illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall; thereby, enabling unimpeded visualization of the cardiac anatomy and intracardiac hemodynamics following rapidly scanning the heart within 10 s. We further applied 3D-PACT to reveal distinct cardiac structural and functional changes among the healthy, hypertensive, and obese rats, with optical contrast to uncover differences in cardiac chamber size, wall thickness, and hemodynamics. Accordingly, 3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing the animal models, holding promises for clinical translation to cardiac imaging of human neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.