Secreted decoy of insulin receptor is required for blood-brain and blood-retina barrier integrity in Drosophila.

Jihyun Kim, Nuri Choi, Jeongsil Kim-Ha

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In one paragraph

Article in BMB reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 100% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

Gene model for the ortholog ofmicroPublication biology · 2025
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4 · The record

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5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jihyun KimDepartment of Integrative Bioscience and Biotechnology, College of Life Sciences, Sejong University, Seoul 05006, Korea.

Nuri ChoiDepartment of Integrative Bioscience and Biotechnology, College of Life Sciences, Sejong University, Seoul 05006, Korea.

Jeongsil Kim-HaDepartment of Integrative Bioscience and Biotechnology, College of Life Sciences, Sejong University, Seoul 05006, Korea.

Sejong University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glial cells play important roles during neurogenesis and in maintaining complex functions of the nervous system. Here, we report the characterization of a gene, Sdr, which contains a putative insulin-like growth factor receptor domain and is required to maintain critical nervous system functions in Drosophila. Sdr is expressed in glial cells during embryonic and larval stages of development, but its role in adult flies is poorly understood. As insulin signaling is important throughout the lifespan in human, we investigated the Sdr's role in adult flies. Our results demonstrate that Sdr is expressed on surface glial cells that surround the nervous system. Mutation of Sdr did not affect development but caused defects in locomotion and lifespan. Sdr mutants also showed increasingly severe defects in the bloodbrain- and blood-retina-barriers as they aged. Therefore, we suggest a novel role of Sdr in maintaining the integrity of the blood-brain- and blood-retina-barriers in adult flies. [BMB Reports 2023; 56(4): 240-245].

Indexed as

DrosophilaDrosophila ProteinsAgedAnimalsBlood-Brain BarrierDrosophila melanogasterHumansNeurogliaReceptor, InsulinRetinaDrosophila ProteinsReceptor, Insulin

Identifiers

PMID36593109

PMCPMC10140486

OpenAlexW4313453998

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LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.