ArticleIn vivo (Athens, Greece)
Study of Hydroxyapatite-coated High-strength Biodegradable Magnesium-based Alloy in Repairing Fracture Damage in Rats.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Experimental study on the application of a novel degradable calcium-phosphate coated magnesium alloy encircling bone plate in the internal fixation of rib fractures.Journal of materials science. Materials in medicine · 2026Article
- Augmenting osteoporotic osseointegration through a temporal release nanocoating-based reversing dysregulated osteogenic microenvironment.Journal of orthopaedic translation · 2025Article
- Review
- Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies.APL bioengineering · 2024Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimHydroxyapatite (HA) coating can improve the degradation rate and biological activity of metallic implants. This study aimed to fabricate a hydroxyapatite-coated ultrafine-grained biodegradable WE43 magnesium (HA/UFG-WE43 Mg) implant for repairing bone fractures. MATERIALS AND
methodsA hybrid approach, including parallel tubular-channel angular pressing (PTCAP) and physical vapour deposition (PVD) magnetron sputtering, was employed. The HA/UFG-WE43 Mg samples were tested in terms of their physicochemical and biological properties.
resultsThe processed tubes exhibited ultrafine structures and the uniformity of microstructures improved following the two-pass PTCAP. The phase composition of the coating formed on UFG-WE43 Mg implant at 250 W for 90 min after heat treatment at 500°C for 60 min confirmed the presence of the HA characteristic peaks. Rat skeletal muscle cells were inoculated on the specimens and cultured for 1, 2, 6, 12, and 24 h, followed by evaluation of cell adhesion and morphology. The growth rates of cells were examined by the Cell Counting Kit8 (CCK-8) and cell survival was observed after 3 days of culture by fluorescence microscopy. The concentration of Mg ions in the blood of rats on 1, 3, 5, 7, and 15 days showed a reduction in Mg concentration after deposition of HA.
conclusionCombination of PTCAP processing followed by surface modification led to tibial fracture healing, and histological analysis of implanted areas demonstrated an efficient biodegradation of the implanted material and a moderate inflammatory reaction.
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