Evidence map›Paper›PMID 36593010›Full record

ArticleIn vivo (Athens, Greece)

Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model.

Yusuke Suzuki, Kazuma Kondo, Kaoru Toyoda, Yuki Tanaka, Akio Kobayashi, Daigo Yokoyama, Hiroyuki Sakakibara

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yusuke SuzukiInterdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki, Miyazaki, Japan.
Kazuma KondoToxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Kanagawa, Japan.
Kaoru ToyodaToxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Kanagawa, Japan.
Yuki TanakaToxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Kanagawa, Japan.
Akio KobayashiDepartment of Pharmaceutical Sciences, International University of Health and Welfare, Tochigi, Japan.
Daigo YokoyamaInterdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki, Miyazaki, Japan.
Hiroyuki SakakibaraInterdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki, Miyazaki, Japan; hiroyuki@cc.miyazaki-u.ac.jp.
Japan Tobacco (Japan) · JPUniversity of Miyazaki · JPInternational University of Health and Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe habitual consumption of excessive fructose is associated with the onset and progression of lifestyle-related diseases, such as nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the physiological changes observed when consuming a diet containing excessive fructose on the viewpoints of hepatotoxicity biological markers using a rat model and explored the biomarker candidates that could detect the effects of excessive fructose intake at an early stage. MATERIALS AND

methodsMale rats were fed 63% high fructose diet (HFrD) ad libitum and their blood samples were collected before and at 1, 2, 3, and 4 weeks after allocation. The plasma biochemical parameters, hepatotoxic enzyme activities including alkaline phosphatase (ALP) isozymes were analyzed.

resultsHFrD consumption for 4-weeks created NAFLD-like symptoms, including elevated plasma lipid parameters and hepatotoxicity markers, as well as fat accumulation in the liver compared with rats consuming a control diet. Alanine aminotransferase (ALT) and glutamate dehydrogenase (GLDH) were increased from the 3

conclusionALP isozyme analysis in combination with GLDH and ALT activities in the plasma samples could be a useful tool to detect the physiological changes induced by excessive fructose intake at an early stage of the development of NAFLD.

Indexed as

Chemical and Drug Induced Liver InjuryNon-alcoholic Fatty Liver DiseaseAnimalsBiomarkersFructoseIsoenzymesLiverMaleRatsBiomarkersFructoseIsoenzymesalkaline phosphatase isozymebiomarkerFructosehepatotoxicitymetabolic syndromenonalcoholic fatty liver disease

Identifiers

PMID36593010
PMCPMC9843779
OpenAlexW4313475110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.