Evidence map›Paper›PMID 36592970›Full record

ArticleJournal of stroke2023

Trends in Venous Thromboembolism Readmission Rates after Ischemic Stroke and Intracerebral Hemorrhage.

Liqi Shu, Adam de Havenon, Ava L Liberman, Nils Henninger, Eric Goldstein, Michael E Reznik, Ali Mahta, Fawaz Al-Mufti, Jennifer Frontera, Karen Furie and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. The dilemma of thromboprophylaxis in stroke patients.Clinical medicine (London, England) · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Managing patients with a history of arterial disease and new venous thromboembolism.Hematology. American Society of Hematology. Education Program · 2025
    Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Liqi ShuDepartment of Neurology, Brown University, Providence, RI, USA.
Adam de HavenonDepartment of Neurology, Yale University, New Haven, CT, USA.
Ava L LibermanDepartment of Neurology, Weill Cornell Medical Center, New York, NY, USA.
Nils HenningerDepartment of Neurology, University of Massachusetts, Worcester, MA, USA.
Eric GoldsteinDepartment of Neurology, Brown University, Providence, RI, USA.
Michael E ReznikDepartment of Neurology, Brown University, Providence, RI, USA.
Ali MahtaDepartment of Neurology, Brown University, Providence, RI, USA.
Fawaz Al-MuftiDepartment of Neurology, Westchester Medical Center, Valhalla, NY, USA.
Jennifer FronteraDepartment of Neurology, New York University, New York, NY, USA.
Karen FurieDepartment of Neurology, Brown University, Providence, RI, USA.
Shadi YaghiDepartment of Neurology, Brown University, Providence, RI, USA.
Brown University · USCornell University · USNew York University · USUniversity of Massachusetts Chan Medical School · USWestchester Medical Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

background and purposeVenous thromboembolism (VTE) is a life-threatening complication of stroke. We evaluated nationwide rates and risk factors for hospital readmissions with VTE after an intracerebral hemorrhage (ICH) or acute ischemic stroke (AIS) hospitalization.

methodsUsing the Healthcare Cost and Utilization Project (HCUP) Nationwide Readmission Database, we included patients with a principal discharge diagnosis of ICH or AIS from 2016 to 2019. Patients who had VTE diagnosis or history of VTE during the index admission were excluded. We performed Cox regression models to determine factors associated with VTE readmission, compared rates between AIS and ICH and developed post-stroke VTE risk score. We estimated VTE readmission rates per day over a 90-day time window post-discharge using linear splines.

resultsOf the total 1,459,865 patients with stroke, readmission with VTE as the principal diagnosis within 90 days occurred in 0.26% (3,407/1,330,584) AIS and 0.65% (843/129,281) ICH patients. The rate of VTE readmission decreased within first 4-6 weeks (P<0.001). In AIS, cancer, obesity, higher National Institutes of Health Stroke Scale (NIHSS) score, longer hospital stay, home or rehabilitation disposition, and absence of atrial fibrillation were associated with VTE readmission. In ICH, longer hospital stay and rehabilitation disposition were associated with VTE readmission. The VTE rate was higher in ICH compared to AIS (adjusted hazard ratio 2.86, 95% confidence interval 1.93-4.25, P<0.001).

conclusionsAfter stroke, VTE readmission risk is highest within the first 4-6 weeks and nearly three-fold higher after ICH vs. AIS. VTE risk is linked to decreased mobility and hypercoagulability. Studies are needed to test short-term VTE prophylaxis beyond hospitalization in high-risk patients.

Indexed as

Acute strokeDeep venous thrombosisPulmonary embolismVenous thromboembolism

Identifiers

PMID36592970
PMCPMC9911841
OpenAlexW4313455011

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.