Evidence map›Paper›PMID 36592872›Full record

ArticleBrain, behavior, and immunity2023

Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus).

Stéphanie G Trouche, Allal Boutajangout, Ayodeji Asuni, Pascaline Fontés, Einar M Sigurdsson, Jean-Michel Verdier, Nadine Mestre-Francés

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stéphanie G TroucheMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France; PSL Research University, Paris, France. Electronic address: stephanie.Sabatier@icm.unicancer.fr.
Allal BoutajangoutDepartments of Neurology, and Neuroscience and Physiology, New York University Grossman School of Medicine, New York, United States. Electronic address: Allal.Boutajangout@nyulangone.org.
Ayodeji AsuniDepartment of Psychiatry, New York University Grossman School of Medicine, New York, United States. Electronic address: asuni@mac.com.
Pascaline FontésMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France. Electronic address: pascaline.fontes@umontpellier.fr.
Einar M SigurdssonDepartments of Neuroscience and Physiology, and Psychiatry, Neuroscience Institute, New York University Grossman School of Medicine, New York, United States. Electronic address: Einar.Sigurdsson@nyulangone.org.
Jean-Michel VerdierMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France; PSL Research University, Paris, France. Electronic address: jean-michel.verdier@ephe.psl.eu.
Nadine Mestre-FrancésMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France; PSL Research University, Paris, France. Electronic address: nadine.frances@umontpellier.fr.
New York University · USUniversité de Montpellier · FRUniversité Paris Sciences et Lettres · FR

Funding

Immune Therapy for AD plaques and Tangles in Tg MiceR01AG020197 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SIGURDSSON, EINAR M · 2001 to 2013
$2.8M
NIA NIH HHS R01 AG020197
6 · The paper itself

Abstract

Non-human primates have an important translational value given their close phylogenetic relationship to humans. Studies in these animals remain essential for evaluating efficacy and safety of new therapeutic approaches, particularly in aging primates that display Alzheimer's disease (AD) -like pathology. With the objective to improve amyloid-β (Aβ) targeting immunotherapy, we investigated the safety and efficacy of an active immunisation with an Aβ derivative, K6Aβ1-30-NH

Indexed as

Alzheimer DiseaseCheirogaleidaeVaccinesAmyloid beta-PeptidesAnimalsDisease Models, AnimalImmunizationPhylogenyVaccinationAmyloid beta-PeptidesVaccinesAgingAmyloid-βImmunisationMicrocebus murinusNon-human primate

Identifiers

PMID36592872
PMCPMC10023341
OpenAlexW4313455295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.