Evidence map›Paper›PMID 36592700›Full record

ArticleNeurochemistry international2023

Selectively compromised inner retina function following hypoxic-ischemic encephalopathy in mice: A noninvasive measure of severity of the injury.

Onur E Taparli, Pawan K Shahi, Nur Sena Cagatay, Nur Aycan, Burak Ozaydin, Sefer Yapici, Xinying Liu, Ulas Cikla, Dila Zafer, Jens C Eickhoff and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Onur E TaparliDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Waisman Center, University of Wisconsin-Madison, WI, USA.
Pawan K ShahiDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, WI, USA.
Nur Sena CagatayDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Waisman Center, University of Wisconsin-Madison, WI, USA.
Nur AycanDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA.
Burak OzaydinDepartment of Neurological Surgery, University of Wisconsin-Madison, WI, USA.
Sefer YapiciDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Waisman Center, University of Wisconsin-Madison, WI, USA.
Xinying LiuDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA.
Ulas CiklaDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Neurological Surgery, University of Wisconsin-Madison, WI, USA.
Dila ZaferDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Waisman Center, University of Wisconsin-Madison, WI, USA.
Jens C EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WI, USA.
Peter FerrazzanoDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Waisman Center, University of Wisconsin-Madison, WI, USA.
Bikash R PattnaikDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, WI, USA. Electronic address: bikashp@pediatrics.wisc.edu.
Pelin CengizDepartment of Pediatrics, University of Wisconsin-Madison, WI, USA; Department of Waisman Center, University of Wisconsin-Madison, WI, USA. Electronic address: cengiz@pediatrics.wisc.edu.
University of Wisconsin–Madison · US

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Sex Differences in Neurotrophin Mediated Neonatal Neuroprotection: Role of ER AlphaR01NS111021 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CENGIZ, PELIN · 2019 to 2023
$1.7M
Molecular Therapies for Lebers Congenital Amaurosis Caused by KCNJ13 MutationsR01EY024995 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PATTNAIK, BIKASH RANJAN · 2015 to 2018
$1.5M
Estrogen receptors and TrkB mediated neuroprotection in neonatal hypoxia-ischemiaK08NS088563 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CENGIZ, PELIN · 2015 to 2019
$994k
Age-dependent microglial responses in hypoxia-ischemiaK08NS078113 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI FERRAZZANO, PETER A · 2013 to 2017
$967k
NEI NIH HHS R01 EY024995NICHD NIH HHS P50 HD105353NINDS NIH HHS K08 NS078113NINDS NIH HHS K08 NS088563NINDS NIH HHS R01 NS111021
6 · The paper itself

Abstract

The intricate system of connections between the eye and the brain implies that there are common pathways for the eye and brain that get activated following injury. Hypoxia-ischemia (HI) related encephalopathy is a consequence of brain injury caused by oxygen and blood flow deprivation that may result in visual disturbances and neurodevelopmental disorders in surviving neonates. We have previously shown that the tyrosine receptor kinase B (TrkB) agonist/modulator improves neuronal survival and long-term neuroprotection in a sexually differential way. In this study, we tested the hypotheses that; 1) TrkB agonist therapy improves the visual function in a sexually differential way; 2) Visual function detected by electroretinogram (ERG) correlates with severity of brain injury detected by magnetic resonance (MRI) imaging following neonatal HI in mice. To test our hypotheses, we used C57/BL6 mice at postnatal day (P) 9 and subjected them to either Vannucci's rodent model of neonatal HI or sham surgery. ERG was performed at P 30, 60, and 90. MRI was performed following the completion of the ERG. ERG in these mice showed that the a-wave is normal, but the b-wave amplitude is severely abnormal, reducing the b/a wave amplitude ratio. Inner retina function was found to be perturbed as we detected severely attenuated oscillatory potential after HI. No sex differences were detected in the injury and severity pattern to the retina as well as in response to 7,8-DHF therapy. Strong correlations were detected between the percent change in b/a ratio and percent hemispheric/hippocampal tissue loss obtained by MRI, suggesting that ERG is a valuable noninvasive tool that can predict the long-term severity of brain injury.

Indexed as

Brain InjuriesHypoxia-Ischemia, BrainAnimalsAnimals, NewbornHypoxiaIschemiaMiceRetina7,8-Dihydroxyflavone (7,8-DHF)Brain-derived neurotrophic factor (BDNF)Electroretinogram (ERG)Hypoxia-ischemia (HI)Tyrosine receptor kinase B (TrkB)

Identifiers

PMID36592700
PMCPMC9905320
OpenAlexW4313305269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.