Evidence map›Paper›PMID 36592421›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Yuanyuan Zhang, Tianxiao Liu, Zhiyong Deng, Wenqian Fang, Xian Zhang, Shuya Zhang, Minjie Wang, Songyuan Luo, Zhaojie Meng, Jing Liu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Emerging Mechanisms of Abdominal Aortic Aneurysm.Current atherosclerosis reports · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Group 2 innate lymphoid cells suppress neuroinflammation and brain injury following intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  12. Article
  13. Exploratory review on the effect ofFrontiers in pharmacology · 2024
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Yuanyuan ZhangHainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research, Key Laboratory of Emergency and Trauma of Ministry of Education, Institute of Cardiovascular Research of the First Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.
Tianxiao LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Zhiyong DengDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Wenqian FangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Xian ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Shuya ZhangHainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research, Key Laboratory of Emergency and Trauma of Ministry of Education, Institute of Cardiovascular Research of the First Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.
Minjie WangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Songyuan LuoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Zhaojie MengDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Jing LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Galina K SukhovaDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Dazhu LiDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Andrew N J McKenzieDivision of Protein & Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Guo-Ping ShiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0001-5809-2567
Junli GuoHainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research, Key Laboratory of Emergency and Trauma of Ministry of Education, Institute of Cardiovascular Research of the First Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.
Brigham and Women's Hospital · USHainan Medical University · CNMRC Laboratory of Molecular Biology · GBShanghai University · CNUnion Hospital · CN

Funding

Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of Mast cells in Alzheimer's DiseaseR01AG063839 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2020 to 2024
$3.1M
Role of group 2 innate lymphoid cells in myocardial infarctionR01HL157073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.7M
Role of ILC2 and eosinophils in abdominal aortic aneurysmR01HL151627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2021 to 2024
$2.7M
Inflammatory Mechanisms of AtherosclerosisR01HL034636 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LIBBY, PETER · 1985 to 2006
$1.9M
CONTROL OF GROWTH OF VASCULAR WALL CELLSR37HL034636 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 1993 to 2002
$1.2M
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2019-I2M-5-023Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College 2019-I2M-5-023Medical Research Council MC_U105178805National Natural Science Foundation of China 82170440National Natural Science Foundation of China U220A20270NHLBI NIH HHS HL151627NHLBI NIH HHS HL157073NHLBI NIH HHS HL34636NHLBI NIH HHS HL80472NHLBI NIH HHS R01 HL034636NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL151627NHLBI NIH HHS R01 HL157073NHLBI NIH HHS R37 HL034636NIA NIH HHS R01 AG063839NINDS NIH HHS AG063839Open program for Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical University KLET-202019Open program for Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical University KLET-202119the Cardiovascular Disease Research Science Innovation Group of Hainan Medical University, Hainan Key Research and Development Fund: ZDYF2021SHFZ089
6 · The paper itself

Abstract

Development of abdominal aortic aneurysms (AAA) enhances lesion group-2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rora

Indexed as

Aortic Aneurysm, AbdominalEosinophilsImmunity, InnateInterleukin-5LymphocytesAnimalsInterleukin-13MiceInterleukin-13Interleukin-5abdominal aortic aneurysmeosinophilGroup-2 innate lymphoid cellIL5

Identifiers

PMID36592421
PMCPMC9982556
OpenAlexW4313454282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.