Trial reportJournal of Parkinson's disease2023
Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease Induces Functional Brain Changes.
Trial report in Journal of Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Cognitive behavioral therapy approaches to the improvement of mental health in Parkinson's disease patients: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Telehealth-delivered cognitive behavioral therapy - a potential solution to improve sleep quality and normalize the salience network in fibromyalgia: a pilot randomized trial.Brain imaging and behavior · 2024Trial
- Non-pharmacological interventions for anxiety and depression in Parkinson's disease.The Cochrane database of systematic reviews · 2026Article
- Perspective: Depression in Persons with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Neural correlates of Parkinson's improvements after combined digital-levodopa therapy: a pilot study.Brain communications · 2026Article
- Cortical thickness alterations in Parkinson's disease related anxiety: A cross-sectional 7 T MRI study.Journal of Parkinson's disease · 2025Article
- Exploring the Efficacy of Cognitive Behavioral Therapy for Managing Anxiety in People with Parkinson's Disease.NeuroSci · 2025Review
- Using Principles of Cognitive Behavioral Therapy to Treat Anxiety in Parkinson's Disease.Movement disorders clinical practice · 2025Review
- Differential large-scale network functional connectivity in cocaine-use disorder associates with drug-use outcomes.Scientific reports · 2025Article
- Reduced volume of the mediodorsal and anteroventral thalamus is associated with anxiety in Parkinson's disease: A cross-sectional 7-tesla MRI study.Journal of Parkinson's disease · 2025Article
- Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Approaches for treating neuropsychiatric symptoms in Parkinson's disease: a narrative review.Therapeutic advances in neurological disorders · 2025Review
- Aberrant functional connectivity and the intrinsic activity of primary visual network and their relationship with adolescent atypical depression symptoms.Frontiers in psychiatry · 2025Article
- A Cognitive-Behavioral Model of Apathy in Parkinson's Disease.Parkinson's disease · 2024Article
- Early identification of Parkinson's disease with anxiety based on combined clinical and MRI features.Frontiers in aging neuroscience · 2024Article
- Non-Pharmacological Interventions for Depression and Anxiety in Parkinson's Disease.Journal of Parkinson's disease · 2024Review
- Anxiety in Parkinson's Disease Is Associated with Changes in Brain Structural Connectivity.Journal of Parkinson's disease · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive behavioral therapy (CBT) reduces anxiety symptoms in patients with Parkinson's disease (PD).
objectiveThe objective of this study was to identify changes in functional connectivity in the brain after CBT for anxiety in patients with PD.
methodsThirty-five patients with PD and clinically significant anxiety were randomized over two groups: CBT plus clinical monitoring (10 CBT sessions) or clinical monitoring only (CMO). Changes in severity of anxiety symptoms were assessed with the Parkinson Anxiety Scale (PAS). Resting-state functional brain MRI was performed at baseline and after the intervention. Functional networks were extracted by an Independent Component Analysis (ICA). Functional connectivity (FC) changes between structures involved in the PD-related anxiety circuits, such as the fear circuit (involving limbic, frontal, and cingulate structures) and the cortico-striato-thalamo-cortical limbic circuit, and both within and between functional networks were compared between groups and regressed with anxiety symptoms changes.
resultsCompared to CMO, CBT reduced the FC between the right thalamus and the bilateral orbitofrontal cortices and increased the striato-frontal FC. CBT also increased the fronto-parietal FC within the central executive network (CEN) and between the CEN and the salience network. After CBT, improvement of PAS-score was associated with an increased striato-cingulate and parieto-temporal FC, and a decreased FC within the default-mode network and between the dorsal attentional network and the language network.
conclusionCBT in PD-patients improves anxiety symptoms and is associated with functional changes reversing the imbalance between PD-related anxiety circuits and reinforcing cognitive control on emotional processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.