ArticleJournal of conservative dentistry : JCD
Efficacy of articaine versus mepivacaine administered as different supplementary local anesthetic techniques after a failed inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: An
Article in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Efficacy of Combined Versus Supplementary Injection Techniques With Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta-Analysis.International endodontic journal · 2025Pooled it
- Diagnostic accuracy of combined pulp sensibility tests for detecting post-anesthetic pulpal anesthesia in mandibular molars with symptomatic irreversible pulpitis.Scientific reports · 2026Trial
- Effect of laser-assisted articaine local anesthesia in single visit root canal treatment for mandibular molar with symptomatic irreversible pulpitis - A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Review
- A comparative clinical study to evaluate the efficacy of lignocaine 2% and articaine 4% for anesthesia of mandibular first molars with irreversible pulpitis.Journal of conservative dentistry and endodontics · 2026Article
- Pain Management in Mandibular Molars With Symptomatic Irreversible Pulpitis: Mechanisms, Clinical Efficacy and Current Evidence: A Narrative Review.Pain research & management · 2026Review
- Comparative evaluation of supplemental buccal infiltration adjuncts for enhancing inferior alveolar nerve block in symptomatic irreversible pulpitis: A randomized double-blind clinical study.Journal of conservative dentistry and endodontics · 2026Article
- Chill before drill: Impact of injection site cooling and cold anesthetic on infiltration anesthesia in symptomatic irreversible pulpitis.Journal of conservative dentistry and endodontics · 2025Article
- Evaluation of three different drugs administered through intraligamentary route for reduction of intraoperative pain of symptomatic irreversible pulpitis in mandibular molars - A randomized triple-blind single-center clinical study.Journal of conservative dentistry and endodontics · 2025Article
- Evaluating the pain at site, onset of action, duration and anesthetic efficacy of conventional, buffered lidocaine, and precooled lidocaine with intraoral cryotherapy application in patients with symptomatic irreversible pulpitis: A clinical study.Journal of conservative dentistry and endodontics · 2024Article
- Review
- Influence of needle gauge on pain perception and use of obturators in achieving profound pulpal anesthesia - A double-blindedJournal of conservative dentistry and endodontics · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The aim of the present study was to assess the efficacy of articaine versus mepivacaine administered as different supplementary local anesthetic techniques after a failed inferior alveolar nerve block (IANB) with lidocaine in patients with irreversible pulpitis. Materials and Methods: A total of 120 patients were included in the study. Patients were given IANB with 2 ml of 2% lidocaine hydrochloride with 1:80,000 epinephrine. Patients who showed subjective symptoms of IANB but did not secure pulpal anesthesia were randomly allocated to one of the following four groups by random sampling for supplementary local anesthesia - Group 1: buccal infiltration (BI) with 4% articaine with 1:100,000 epinephrine, Group 2: four-site intraligamentary (IL) injection with 4% articaine with 1:100,000 epinephrine, Group 3: BI with 2% mepivacaine with 1:100,000 epinephrine, and Group 4: four-site IL injection with 2% mepivacaine with 1:100,000 epinephrine. Results: Group 1 - BI with articaine provided anesthesia success in 27 cases (90%, Conclusion: In patients with a mandibular first molar exhibiting symptomatic irreversible pulpitis, block injection with lidocaine along with supplemental BI with articaine allowed more pain-free treatments. Articaine showed better results when compared with mepivacaine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.