Evidence map›Paper›PMID 36591329›Full record

ArticleTransplantation direct2023

Australian Donation and Transplantation Biobank: A Research Biobank Integrated Within a Deceased Organ and Tissue Donation Program.

Varun J Sharma, Graham Starkey, Rohit D'Costa, Fiona James, Effie Mouhtouris, Lisa Davis, Boa Zhong Wang, Angela Vago, Jaishankar Raman, Laura K Mackay and 5 more

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. TNF-⍺-mediated myeloid-instructed CD14Cell reports. Medicine · 2026
    Article
  2. The INTEGRITY guidelines - ethical guidance for research involving deceased donation and transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Varun J SharmaDepartment of Surgery (Austin Health), Melbourne Medical School, The University of Melbourne, VIC, Melbourne, Australia.
Graham StarkeyDepartment of Surgery (Austin Health), Melbourne Medical School, The University of Melbourne, VIC, Melbourne, Australia.
Rohit D'CostaDonateLife Victoria, Carlton, VIC, Australia.
Fiona JamesDepartment of Infectious Diseases, Austin Health, Melbourne, VIC, Australia.
Effie MouhtourisDepartment of Infectious Diseases, Austin Health, Melbourne, VIC, Australia.
Lisa DavisDepartment of Infectious Diseases, Austin Health, Melbourne, VIC, Australia.
Boa Zhong WangDepartment of Surgery (Austin Health), Melbourne Medical School, The University of Melbourne, VIC, Melbourne, Australia.
Angela VagoLiver & Intestinal Transplant Unit, Austin Health, Melbourne, VIC, Australia.
Jaishankar RamanDepartment of Surgery (Austin Health), Melbourne Medical School, The University of Melbourne, VIC, Melbourne, Australia.
Laura K MackayDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Helen OpdamDepartment of Intensive Care Medicine, Austin Health, Melbourne, VIC, Australia.
Robert JonesDepartment of Surgery (Austin Health), Melbourne Medical School, The University of Melbourne, VIC, Melbourne, Australia.
M Lindsay GraysonDepartment of Infectious Diseases, Austin Health, Melbourne, VIC, Australia.
Dominique E MartinSchool of Medicine, Deakin University, Geelong, VIC, Australia.
Claire L GordonDepartment of Infectious Diseases, Austin Health, Melbourne, VIC, Australia.
Austin Health · AUPeter Doherty Institute · AUDeakin University · AUOctober 6 University · EGUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to facilitate the donation of tissue samples for research by establishing a centralized system integrated in the organ donation program for collection, storage, and distribution of samples (the Australian Donation and Transplantation Biobank [ADTB]). Methods: Feasibility of a research biobank integrated within the deceased organ and tissue donation program was assessed. DonateLife Victoria sought consent for ADTB donation after consent was received for organ donation for transplantation from the donor's senior available next of kin. ADTB samples were collected during donation surgery and distributed fresh to researchers or stored for future research. The main outcome measures were ADTB donation rates, ADTB sample collection, ADTB sample use, and to identify ethical considerations. Results: Over 2 y, samples were collected for the ADTB from 69 donors (28% of 249 donors). Samples were obtained from the spleen (n = 59, 86%), colon (n = 57, 83%), ileum (n = 56, 82%), duodenum (n = 55, 80%), blood (n = 55, 80%), bone marrow (n = 55, 80%), skin (n = 54, 78%), mesenteric lymph nodes (n = 56, 81%), liver (n = 21, 30%), lung (n = 29, 42%), and lung-draining lymph node (n = 29, 42%). Heart (n = 20), breast (n = 1), and lower urinary tract (n = 1) samples were obtained in the second year. Five hundred fifty-six samples were used in 19 ethics-approved research projects spanning the fields of immunology, microbiology, oncology, anatomy, physiology, and surgery. Conclusions: The integration of routine deceased donation and transplantation activities with a coordinated system for retrieval and allocation of donor samples for use in a range of research projects is feasible and valuable.

Identifiers

PMID36591329
PMCPMC9750700
OpenAlexW4312185540

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.