Evidence map›Paper›PMID 36591282›Full record

ArticleFrontiers in immunology2022

Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU).

S M Zahid Hosen, Md Nazim Uddin, Zhihong Xu, Benjamin J Buckley, Chamini Perera, Tony C Y Pang, Alpha Raj Mekapogu, Mohammad Ali Moni, Faiyaz Notta, Steven Gallinger and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

S M Zahid HosenPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Md Nazim UddinInstitute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Zhihong XuPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Benjamin J BuckleyMolecular Horizons and School of Chemistry & Molecular Bioscience, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
Chamini PereraPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Tony C Y PangPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Alpha Raj MekapoguPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Mohammad Ali MoniSchool of Health and Rehabilitation Sciences, Faculty of Health and Behavioural Sciences, The University of Queensland, St Lucia, QLD, Australia.
Faiyaz NottaPanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Steven GallingerPanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Ron PirolaPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Jeremy WilsonPancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Marie RansonMolecular Horizons and School of Chemistry & Molecular Bioscience, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
David GoldsteinPrince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Minoti AptePancreatic Research Group, SWS Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.
Ingham Institute · AUUNSW Sydney · AUIllawarra Health and Medical Research Institute · AUOntario Institute for Cancer Research · CABangladesh Council of Scientific and Industrial Research · BDPrince of Wales Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by Methods: This study used an integrated bioinformatics approach to identify prognostic markers correlated with PLAU expression using different transcriptomics, proteomics, and clinical data sets. We then determined the association of dysregulated Results: Our analyses revealed that Conclusion: Elevated

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsTumor MicroenvironmentHumansMembrane ProteinsPhenotypeUrokinase-Type Plasminogen ActivatorMembrane ProteinsPLAU protein, humanUrokinase-Type Plasminogen ActivatorECM degradationEMTimmune suppression and basal subtype type of PDACpancreatic stellate cellsPLAUproliferationstemness

Identifiers

PMID36591282
PMCPMC9794594
OpenAlexW4311325417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.