ArticleFrontiers in immunology2022
Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- SwarmMAP: swarm learning for decentralized cell type annotation in single cell sequencing data.NPJ systems biology and applications · 2026Article
- Single-Cell RNA-Seq Profiling of Transposable Element Expression in Human Peripheral Blood Cells During Viral Infections.International journal of molecular sciences · 2026Article
- Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters.Cell reports · 2025Article
- The Impact of Vaccination Frequency on COVID-19 Public Health Outcomes: A Model-Based Analysis.Vaccines · 2025Article
- SwarmMAP: Swarm Learning for Decentralized Cell Type Annotation in Single Cell Sequencing Data.bioRxiv : the preprint server for biology · 2025Article
- Unraveled role of TLR7-mediated interferon signaling activation in COVID-19.Frontiers in cellular and infection microbiology · 2025Review
- Single-cell transcriptomics reveals systemic immune dysregulation in non-segmental vitiligo.Frontiers in immunology · 2025Article
- Single-Cell Sequencing Redefines Immune Heterogeneity and Communication Networks in ARDS: Toward Precision Therapeutics.International journal of genomics · 2025Review
- The characterization of CD8Emerging microbes & infections · 2024Review
- Article
- Cellular and immune response in fatal COVID-19 pneumonia.The Pan African medical journal · 2024Article
- Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single-cell RNA sequencing.Microbiology spectrum · 2023Article
- Article
- Alterations in the CD56International journal of molecular sciences · 2023Article
- Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing.bioRxiv : the preprint server for biology · 2023Article
- mRNA-1273 boost after BNT162b2 vaccination generates comparable SARS-CoV-2-specific functional responses in naïve and COVID-19-recovered individuals.Frontiers in immunology · 2023Article
- Bioinformatic Analysis of B- and T-cell Epitopes from SARS-CoV-2 Structural Proteins and their Potential Cross-reactivity with Emerging Variants and other Human Coronaviruses.Archives of medical research · 2022Article
- SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8Nature immunology · 2022Article
- In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022Article
- SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells.medRxiv : the preprint server for health sciences · 2022Article
Corrections and comments
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Authors and funding
29 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants. Methods: We combined single-cell RNA and T cell receptor sequencing with CITE-seq antibodies to characterize the CD8 Results: We observed increased CD8 Discussion: We propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.