Observational studyFrontiers in immunology2022
The blood pressure targets in sepsis patients with acute kidney injury: An observational cohort study of multiple ICUs.
Observational study in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Net renal perfusion - an emerging concept during development of AKI in the critically ill.Renal failure · 2026Article
- Prognostic Factors and Risk Stratification in Malignant Tumor Patients With Sepsis: A Retrospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Age-Specific Prognostic Models for Sepsis-Associated Acute Kidney Injury: A Multicenter Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Exploring the optimal range of blood pressure in elderly sepsis patients: a retrospective cohort study based on MIMIC-IV data.BMC infectious diseases · 2025Article
- Association between renal mean perfusion pressure and prognosis in patients with sepsis-associated acute kidney injury: insights from the MIMIC IV database.Renal failure · 2025Article
- Machine learning-based risk prediction model development for acute kidney injury in type 2 myocardial infarction patients.Scientific reports · 2025Article
- Acute Kidney Injury Among Patients Undergoing Orthopedic Surgery and Admitted to the ICU: A Retrospective Analysis of Nonoperative Risk Factors.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Fibrinogen-to-Albumin Ratio Predicts Acute Kidney Injury in Very Elderly Acute Myocardial Infarction Patients.Biomedicines · 2025Article
- Non-linear associations between renal perfusion pressure indexes and AKI incidence and recovery rate.European journal of medical research · 2025Article
- Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2025Article
- Optimal target mean arterial pressure for patients with sepsis-associated encephalopathy: a retrospective cohort study.BMC infectious diseases · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The maintenance of blood pressure is pivotal in preventing sepsis with acute kidney injury (AKI). Especially in sepsis patients treated with vasopressors. The optimal the blood pressure has been controversial to maintain renal perfusion. This study aims to explore the blood pressure target in sepsis with AKI. Methods: We retrieved patient data from the MIMIC IV and eICU databases. The Lasso regression model was used to identify the relationship between blood pressure and sepsis in patients with AKI and remove collinearity among variables. Generalized additive models were used to estimate the blood pressure range in patients with sepsis with AKI. Statistical methods such as multivariable logistic regression, propensity score analysis, inversion probability-weighting, and doubly robust model estimation were used to verify the target blood pressure for patients with sepsis and AKI. Results: In total, 17874 patients with sepsis were included in this study. the incidence of AKI may be related to the level of mean article pressure (MAP) and diastolic blood pressure (DBP) in sepsis patients. The range of MAPs and DBPs may be 65-73 mmHg and 50-60 mmHg in AKI patients without hypertension. The range of MAPs and DBPs may be 70-80 mmHg and 54-62 mmHg in AKI patients with hypertension. The prognosis of sepsis with AKI was unaffected by MAP or DBP. Systolic blood pressure is not associated with sepsis in patients with AKI. Conclusions: To ensure renal perfusion, AKI patients with hypertension may require a higher MAP [70-80] versus (65-73), mmHg] and DBP [(54-62) vs (50-60), mmHg] than patients without hypertension.
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