Evidence map›Paper›PMID 36591136›Full record

ArticleACS omega2022

Pharmaceutical and Pharmacological Evaluation of Amoxicillin after Solubility Enhancement Using the Spray Drying Technique.

Faiza Hassan, Muhammad Sher, Muhammad Ajaz Hussain, Mubshara Saadia, Muhammad Naeem-Ul-Hassan, Muhammad Fayyaz Ur Rehman, Muhammad Tahir Haseeb, Syed Nasir Abbas Bukhari, Azhar Abbas, Bo Peng and 2 more

Abstract read
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In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Faiza HassanInstitute of Chemistry, University of Sargodha, Sargodha40100, Pakistan.
Muhammad SherInstitute of Chemistry, University of Sargodha, Sargodha40100, Pakistan.
Muhammad Ajaz HussainSchool of Chemistry, University of the Punjab, Lahore54600, Pakistan.ORCID https://orcid.org/0000-0003-4570-6616
Mubshara SaadiaDepartment of Chemistry, Ghazi University, Dera Ghazi Khan32200, Pakistan.
Muhammad Naeem-Ul-HassanInstitute of Chemistry, University of Sargodha, Sargodha40100, Pakistan.
Muhammad Fayyaz Ur RehmanInstitute of Chemistry, University of Sargodha, Sargodha40100, Pakistan.ORCID https://orcid.org/0000-0003-2901-7212
Muhammad Tahir HaseebCollege of Pharmacy, University of Sargodha, Sargodha40100, Pakistan.ORCID https://orcid.org/0000-0002-1883-7226
Syed Nasir Abbas BukhariDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aliouf2014, Saudi Arabia.
Azhar AbbasInstitute of Chemistry, University of Sargodha, Sargodha40100, Pakistan.
Bo PengGovernment Ambala Muslim Graduate College, Sargodha40100, Pakistan.
Fariha KanwalSchool of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai201620, China.
Huibiao DengDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dose frequency of drugs belonging to class II is usually high and associated with harmful effects on the body. The study aimed to enhance the solubility of the poorly water-soluble drug amoxicillin (AM) by the solid dispersion (SD) technique. Six different SDs of AM, F1-F6, were prepared by the spray drying technique using two other carriers, HP-β-CD (F1-F3) and HPMC (F4-F6), in 1:1, 1:2, and 1:3 drug-to-polymer ratios. These SDs were analyzed to determine their practical yield, drug content, and aqueous solubility using analytical techniques such as Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and powder X-ray diffraction. The effect of polymer concentration on SDs was determined using aqueous solubility,

Identifiers

PMID36591136
PMCPMC9798760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.