Evidence map›Paper›PMID 36590867›Full record

ArticleInterdisciplinary nursing research2022

Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization.

Jie Chen, Hongfei Li, Kendra Maas, Angela Starkweather, Minghui Chen, Xiaomei Cong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interdisciplinary nursing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jie ChenSchool of Nursing, University of Connecticut, Storrs, CT, USA.
Hongfei LiDepartment of Statistics, University of Connecticut, Storrs, CT, USA.
Kendra MaasMicrobial Analysis, Resources, and Services (MARS), University of Connecticut, Storrs, CT, USA.
Angela StarkweatherCollege of Nursing, University of Florida, Gainesville, FL, USA.
Minghui ChenDepartment of Statistics, University of Connecticut, Storrs, CT, USA.
Xiaomei CongSchool of Nursing, University of Connecticut, Storrs, CT, USA.
University of Connecticut · USFederal Reserve · USUniversity of Florida · US

Funding

Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm InfantsR01NR016928 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2017 to 2020
$2.5M
Early Life Experience Imprints Gut Microbiome in Preterm InfantsK23NR014674 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2013 to 2015
$396k
NINR NIH HHS K23 NR014674NINR NIH HHS R01 NR016928
6 · The paper itself

Abstract

Objectives: The gut microbiota among preterm infants is shaped by sex and feeding types. However, sex-specific weekly patterns of gut microbiome profiles among preterm infants during their neonatal intensive care unit (NICU) hospitalization remain unclear. This study aimed to investigate the effect of sex on the weekly development of preterm neonatal gut microbiota in the first 4 weeks of NICU hospitalization. Methods: This secondary data analysis included 28 preterm neonates with 261 stool samples collected from January 2014 to February 2015 in the Northeastern United States. The 16S rRNA V4 gene regions of the stool samples were sequenced and aligned against the SILVA 132 database by using Mothur 1.42.3. The sex-specific weekly diversity indexes and relative abundance of bacterial taxonomic composition were generated by Mothur and analyzed by R packages. Sex-specific weekly compositional patterns of the gut microbiome and predicted metabolic functions of gut microbiome profiles were compared, respectively. Results: In each week of the NICU hospitalization, preterm females and males had significantly distinguished β-diversity indices and compositions of gut microbiota. Both females and males had significantly enriched Conclusions: Sex shaped the weekly patterns of preterm neonatal gut microbiome profiles during the first 4 weeks of the NICU hospitalization. Further clinical interventions should consider the distinct gut microbiota compositions and predicted functional profiles between female and male preterm neonates.

Indexed as

16S rRNACompositionGut microbiotaPreterm neonatesSex

Identifiers

PMID36590867
PMCPMC9766955
OpenAlexW4310477152

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.