Evidence map›Paper›PMID 36590866›Full record

ArticleInterdisciplinary nursing research2022

Trends of fecal calprotectin levels and associations with early life experience in preterm infants.

Wanli Xu, Yiming Zhang, Wenxiao Zhao, Jie Chen, Kendra Maas, Naveed Hussain, Wendy A Henderson, Xiaomei Cong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interdisciplinary nursing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Effect ofNutrients · 2023
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Wanli XuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yiming ZhangGraduate School of Social Work, University of Denver, Denver, Colorado, USA.
Wenxiao ZhaoSchool of Nursing, Shandong University of Traditional Chinese Medicine, Shandong, China.
Jie ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Kendra MaasMicrobial Analysis, Resources, and Services, University of Connecticut, Storrs, CT, USA.
Naveed HussainDepartment of Pediatrics, School of Medicine, University of Connecticut, Farmington, CT, USA.
Wendy A HendersonDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Xiaomei CongDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0002-4992-199X
Peking University · CNUniversity of Connecticut · USShandong University of Traditional Chinese Medicine · CNUniversity of Denver · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Preterm infants are at risk for severe infections due to their immature immune systems. Factors such as early life pain/stress experiences and feeding may influence immune activation and maturation of immune systems. However, the underlying mechanism remains unclear. Fecal calprotectin (FCP) is a noninvasive surrogate biomarker of mucosal inflammation in the gastrointestinal tract and has been used in detecting intestinal inflammation in specific pediatric gastrointestinal disorders. Objective: To describe the longitudinal trajectory of FCP levels in preterm infants and investigate the contributing factors that are associated with FCP levels. Design: A longitudinal study design was used. Settings: Preterm infants were recruited from 2 neonatal intensive care units (NICU) of a children's medical center in the North-eastern US. Methods: Preterm infants were followed during their first 4 weeks of NICU hospitalization. Stool samples were collected twice per week to quantify the FCP levels. Cumulative pain/stress experiences and feeding types were measured daily. A linear mixed-effect model was used to examine the associations between FCP levels and demographic and clinical characteristics, cumulative pain/stress, and feeding over time. Results: Forty-nine preterm infants were included in the study. Infants' FCP levels varied largely with a mean of 268.7±261.3 µg/g and increased over time. Preterm infants experienced an average of 7.5±5.0 acute painful procedures and 15.3±20.8 hours of chronic painful procedures per day during their NICU stay. The mean percentage of mother's own milk increased from the first week (57.1±36.5%) to the fourth week (60.7±38.9%) after birth. Elevated FCP concentration was associated with acute and cumulative (chronic) pain/stress levels, mother's own milk, non-White race, and higher severity of illness score. Conclusions: FCP levels were elevated in preterm infants with wide interindividual and intraindividual variations. Cumulative pain/stress during the NICU hospitalization, feeding, race, and health status may influence FCP concentrations in early life that may be associated with inflammatory gut processes.

Indexed as

Fecal calprotectinGut inflammationPainPreterm infantStress

Identifiers

PMID36590866
PMCPMC9766919
OpenAlexW4310655209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.