ArticleInternational journal of pharmaceutics: X2023
Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy.
Article in International journal of pharmaceutics: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed.
- Process Analytical Technology Integration in 3D Printing Processes: Benefits and Challenges.AAPS PharmSciTech · 2026Review
- Quality by Design and Process Analytical Technology for On-Demand Drug Manufacturing Through 3D Printing.Pharmaceutics · 2026Review
- 3D-printed polypills for personalized medicine and precision oral drug delivery in pharmaceutical practice: A review.International journal of pharmaceutics: X · 2026Review
- From Digital Design to Dosage Performance: Material-Process-Geometry Interactions in 3D-Printed Oral Tablets.AAPS PharmSciTech · 2026Review
- In Silico Predictions Driving the Development of 3D-Printed Drug Delivery Systems.Pharmaceutics · 2025Article
- Three-Dimensional Printing in Paediatrics: Innovative Technology for Manufacturing Patient-Centred Drug Delivery Systems.Pharmaceutics · 2025Review
- Selective Laser Sintering of Atomoxetine Tablets: An Innovative Approach for Small-Scale, Personalized Production.Pharmaceutics · 2025Article
- Selective laser sintering of distinct drug and polymer layers as a novel manufacturing strategy for individually dosed tablets.International journal of pharmaceutics: X · 2025Article
- Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels.Drug delivery and translational research · 2025Article
- Use of Computational Intelligence in Customizing Drug Release from 3D-Printed Products: A Comprehensive Review.Pharmaceutics · 2025Review
- Revealing Three-Dimensional Printing Technology Advances for Oral Drug Delivery: Application to Central-Nervous-System-Related Diseases.Pharmaceutics · 2025Review
- Emerging 3D printing technologies for solid oral dosage forms: Processes, materials and analytical tools for real-time assessment.International journal of pharmaceutics · 2025Review
- Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering.ACS biomaterials science & engineering · 2025Article
- Selective Laser Sintering 3D Printing of Carvedilol Tablets: Enhancing Dissolution Through Amorphization.Pharmaceutics · 2024Article
- Review
- Prediction of cyanidin 3-rutinoside content inFrontiers in plant science · 2024Article
- Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms.International journal of pharmaceutics: X · 2023Article
- Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing.International journal of pharmaceutics: X · 2023Article
- A case study on decentralized manufacturing of 3D printed medicines.International journal of pharmaceutics: X · 2023Article
- Virtually Possible: Enhancing Quality Control of 3D-Printed Medicines with Machine Vision Trained on Photorealistic Images.Pharmaceutics · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective laser sintering (SLS) 3D printing is a revolutionary 3D printing technology that has been found capable of creating drug products with varied release profiles by changing the laser scanning speed. Here, SLS 3D printed formulations (printlets) loaded with a narrow therapeutic index drug (theophylline) were produced using SLS 3D printing at varying laser scanning speeds (100-180 mm/s). The use of reflectance Fourier Transform - Near Infrared (FT-NIR) spectroscopy was evaluated as a non-destructive approach to predicting 3D printed tablet density and drug release at 2 h and 4 h. The printed drug products formulated with a higher laser speed exhibited an accelerated drug release and reduced density compared with the slower laser scanning speeds. Univariate calibration models were developed based on a baseline shift in the spectra in the third overtone region upon changing physical properties. For density prediction, the developed univariate model had high linearity (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.