Evidence map›Paper›PMID 36590736›Full record

ArticleJTCVS open2022

Outcomes after heart transplantation in patients who have undergone a bridge-to-bridge strategy.

Alice L Zhou, Eric W Etchill, Benjamin L Shou, James J Whitbread, Iulia Barbur, Katherine A Giuliano, Ahmet Kilic

Open access · goldAbstract read
In one paragraph

Article in JTCVS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Extracorporeal biventricular support through left mini-thoracotomy.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alice L ZhouJohns Hopkins University School of Medicine, Baltimore, Md.
Eric W EtchillDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Benjamin L ShouJohns Hopkins University School of Medicine, Baltimore, Md.
James J WhitbreadJohns Hopkins University School of Medicine, Baltimore, Md.
Iulia BarburJohns Hopkins University School of Medicine, Baltimore, Md.
Katherine A GiulianoDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Ahmet KilicDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: We compared posttransplant outcomes between patients bridged from temporary mechanical circulatory support to durable left ventricular assist device before transplant (bridge-to-bridge [BTB] strategy) and patients bridged from temporary mechanical circulatory support directly to transplant (bridge-to-transplant [BTT] strategy). Methods: We identified adult heart transplant recipients in the Organ Procurement and Transplantation Network database between 2005 and 2020 who were supported with extracorporeal membrane oxygenation, intra-aortic balloon pump, or temporary ventricular assist device as a BTB or BTT strategy. Kaplan-Meier survival analysis and Cox regressions were used to assess 1-year, 5-year, and 10-year survival. Posttransplant length of stay and complications were compared as secondary outcomes. Results: In total, 201 extracorporeal membrane oxygenation (61 BTB, 140 BTT), 1385 intra-aortic balloon pump (460 BTB, 925 BTT), and 234 temporary ventricular assist device (75 BTB, 159 BTT) patients were identified. For patients supported with extracorporeal membrane oxygenation, intra-aortic balloon pump, or temporary ventricular assist device, there were no differences in survival between BTB and BTT at 1 and 5 years posttransplant, as well as 10 years posttransplant even after adjusting for baseline characteristics. The extracorporeal membrane oxygenation BTB group had greater rates of acute rejection (32.8% vs 13.6%; Conclusions: BTB patients have similar short- and midterm posttransplant survival as BTT patients. Future studies should continue to investigate the tradeoff between prolonged temporary mechanical circulatory support versus transitioning to durable mechanical circulatory support.

Indexed as

BTB, bridge-to-bridgeBTT, bridge-to-transplantCO, cardiac outputECMO, extracorporeal membrane oxygenationextracorporeal membrane oxygenationheart transplantIABP, intra-aortic balloon pumpintra-aortic balloon pumpLVAD, left ventricular assist deviceMCS, mechanical circulatory supportmechanical circulatory supportmPAP, mean pulmonary arterial pressureOPTN, Organ Procurement and Transplantation NetworkPA, pulmonary arteryPCWP, pulmonary capillary wedge pressureTAH, total artificial hearttransplant outcomestVAD, temporary ventricular assist deviceUNOS, United Network for Organ Sharingventricular assist devices

Identifiers

PMID36590736
PMCPMC9801290
OpenAlexW4295123501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.