Evidence map›Paper›PMID 36590712›Full record

ArticleJTCVS open2022

Location matters: Offset in tissue-engineered vascular graft implantation location affects wall shear stress in porcine models.

Jacqueline Contento, Paige Mass, Vincent Cleveland, Seda Aslan, Hiroshi Matsushita, Hidenori Hayashi, Vivian Nguyen, Keigo Kawaji, Yue-Hin Loke, Kevin Nelson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jacqueline ContentoDepartment of Cardiology, Children's National Hospital, Washington, DC.
Paige MassDepartment of Cardiology, Children's National Hospital, Washington, DC.
Vincent ClevelandDepartment of Cardiology, Children's National Hospital, Washington, DC.
Seda AslanLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, Md.
Hiroshi MatsushitaDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Hidenori HayashiDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Vivian NguyenDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.
Keigo KawajiDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.
Yue-Hin LokeDepartment of Cardiology, Children's National Hospital, Washington, DC.
Kevin NelsonNanofiber Solutions, LLC, Dublin, Ohio.
Jed JohnsonNanofiber Solutions, LLC, Dublin, Ohio.
Axel KriegerLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, Md.
Laura OlivieriDepartment of Cardiology, Children's National Hospital, Washington, DC.
Narutoshi HibinoDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.

Funding

Patient specific 3D printed tissue engineered vascular graft for aortic reconstruction designed by artificial intelligence algorithm.R01HL143468 · NHLBI · UNIVERSITY OF CHICAGO · PI FUGE, MARK, HIBINO, NARUTOSHI · 2018 to 2021
$2.7M
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR33HD090671 · NICHD · UNIVERSITY OF CHICAGO · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2019 to 2021
$1.2M
MR Quantification of Myocardial Oxygen Utilization in Chronic Myocardial Infarction without ContrastK25HL141634 · NHLBI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI KAWAJI, KEIGO · 2019 to 2023
$831k
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR21HD090671 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2017 to 2018
$484k
NHLBI NIH HHS K25 HL141634NHLBI NIH HHS R01 HL143468NICHD NIH HHS R21 HD090671NICHD NIH HHS R33 HD090671
6 · The paper itself

Abstract

Objective: Although surgical simulation using computational fluid dynamics has advanced, little is known about the accuracy of cardiac surgical procedures after patient-specific design. We evaluated the effects of discrepancies in location for patient-specific simulation and actual implantation on hemodynamic performance of patient-specific tissue-engineered vascular grafts (TEVGs) in porcine models. Methods: Magnetic resonance angiography and 4-dimensional (4D) flow data were acquired in porcine models (n = 11) to create individualized TEVGs. Graft shapes were optimized and manufactured by electrospinning bioresorbable material onto a metal mandrel. TEVGs were implanted 1 or 3 months postimaging, and postoperative magnetic resonance angiography and 4D flow data were obtained and segmented. Displacement between intended and observed TEVG position was determined through center of mass analysis. Hemodynamic data were obtained from 4D flow analysis. Displacement and hemodynamic data were compared using linear regression. Results: Patient-specific TEVGs were displaced between 1 and 8 mm during implantation compared with their surgically simulated, intended locations. Greater offset between intended and observed position correlated with greater wall shear stress (WSS) in postoperative vasculature ( Conclusions: Patient-specific TEVGs are designed for precise locations to help optimize hemodynamic performance. However, if TEVGs were implanted far from their intended location, worse WSS was observed. This underscores the importance of not only patient-specific design but also precision-guided implantation to optimize hemodynamics in cardiac surgery and increase reproducibility of surgical simulation.

Indexed as

4D, four-dimensionalAR, augmented realitycenter of gravityCFD, computational fluid dynamicsCHD, congenital heart diseasecomputational fluid dynamicsdisplacementhemodynamicsLPA, left pulmonary arteryMPA, main pulmonary arteryMRA, magnetic resonance angiographyMRI, magnetic resonance imagingPA, pulmonary arteryRPA, right pulmonary arterySCA, subclavian arterySTL, stereolithographysurgical planningTEVG, tissue-engineered vascular grafttissue-engineered vascular graftswall shear stressWSS, wall shear stressαSMA, α-smooth muscle actin

Identifiers

PMID36590712
PMCPMC9801286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.