Evidence map›Paper›PMID 36590689›Full record

ArticleCell reports methods2022

Head-mounted optical imaging and optogenetic stimulation system for use in behaving primates.

Derek Zaraza, Mykyta M Chernov, Yiyuan Yang, John A Rogers, Anna W Roe, Robert M Friedman

Open access · goldAbstract read
In one paragraph

Article in Cell reports methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Journal of neural engineering · 2024
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Derek ZarazaDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Mykyta M ChernovDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Yiyuan YangDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
John A RogersDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
Anna W RoeDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Robert M FriedmanDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Oregon National Primate Research Center · USNorthwestern University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Neural basis of tactile object perception in SI cortexR01NS093998 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRIEDMAN, ROBERT MARK · 2016 to 2020
$2.9M
Wireless optical imaging, optogenetic stimulation and neurophysiological recording to study to neural foundations of natural freely moving behaviors in primates.R21EY031073 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRIEDMAN, ROBERT MARK · 2020 to 2021
$463k
NEI NIH HHS R21 EY031073NIH HHS P51 OD011092NINDS NIH HHS R01 NS093998
6 · The paper itself

Abstract

Advances in optical technology have revolutionized studies of brain function in freely behaving mice. Here, we describe an optical imaging and stimulation device for use in primates that easily attaches to an intracranial chamber. It consists of affordable commercially available or 3D-printed components: a monochromatic camera, a small standard lens, a wireless μLED stimulator powered by an induction coil, and an LED array for illumination. We show that the intrinsic imaging performance of this device is comparable to a standard benchtop system in revealing the functional organization of the visual cortex for awake macaques in a primate chair or under anesthesia. Imaging revealed neural modulatory effects of wireless focal optogenetic stimulation aimed at identified functional domains. With a 1 to 2 cm field of view, 100× larger than previously used in primates without head restraint, our device permits widefield optical imaging and optogenetic stimulation for ethological studies in primates.

Indexed as

OptogeneticsVisual CortexAnimalsMiceOptical ImagingPrimatesVision, Ocularimaging systemintrinsic optical imagingmacaquemesoscaleoptogenetic stimulationvisual cortexwidefield imaging

Identifiers

PMID36590689
PMCPMC9795332
OpenAlexW4309593076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.