Evidence map›Paper›PMID 36590565›Full record

ArticleHeliyon2022

Clinical characteristics and severity of beta and delta variants of SARS-CoV-2 and the effect of vaccine on delta variants.

Yahui Peng, Wei Yang, Yuxin Zhou, Dongsheng Fei, Kai Kang, Xianglin Meng, Mingyan Zhao, Xiaomin Liu, Shihuan Yu, Feiyu Luan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yahui PengDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Wei YangDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Yuxin ZhouDepartment of Critical Care Medicine, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150081, China.
Dongsheng FeiDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Kai KangDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Xianglin MengDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Mingyan ZhaoDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Xiaomin LiuRespiratory Department, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, China.
Shihuan YuRespiratory Department, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, China.
Feiyu LuanSurgical Emergency, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, China.
Xiaohui MaDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Xiaonan JiaDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Wenjing MuDepartment of Critical Care Medicine, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150081, China.
Changsong WangDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Kaijiang YuDepartment of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Delta variant of concern (VOC) is rapidly becoming the dominant strain globally. We report the clinical characteristics and severity of hospitalized patients infected with Delta and Beta VOCs during the local outbreak in Harbin, Heilongjiang Province, China, and the effect of vaccines on the Delta variant. Methods: We collected a total of 735 COVID-19 patients from the First Affiliated Hospital of Harbin Medical University, including 96 cases infected with the Delta VOC and 639 cases infected with the Beta VOC. Demographic, clinical characteristic and laboratory findings were collected and compared. Results: Differences in viral shedding, IgG and IgM levels, and the neutrophil-to-lymphocyte ratio were noted between the Delta and Beta VOCs (p < 0.05). Survival analysis of the two groups revealed longer viral shedding of the Delta VOC (p < 0.05). For the Delta VOC, the longer the vaccination period, the lower the IgG and IgM levels. IgM levels were higher in the convalescent plasma group, whereas lymphocyte counts were lower. Conclusions: Delta VOC virus shedding was longer compared with Beta VOC shedding. Vaccination with inactivated vaccines can reduce the severe illness rate of the Delta VOC. IgG and IgM levels are reduced as the time period between the first and second vaccine doses increases.

Indexed as

Convalescent plasmaCOVID-19Delta variantsIgGIgMInactivated vaccinesVirus shedding

Identifiers

PMID36590565
PMCPMC9789541

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.