Evidence map›Paper›PMID 36590505›Full record

ArticleHeliyon2022

New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice.

Makan Golizeh, John Nam, Eric Chatelain, Yves Jackson, Leanne B Ohlund, Asieh Rasoolizadeh, Fabio Vasquez Camargo, Louiza Mahrouche, Alexandra Furtos, Lekha Sleno and 1 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Alterations in Cardiac Metabolism byACS infectious diseases · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Persistent biofluid small molecule alterations induced bybioRxiv : the preprint server for biology · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Makan GolizehDepartment of Mathematical and Physical Sciences, Concordia University of Edmonton, Edmonton, Alberta, Canada.
John NamNational Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Eric ChatelainDrugs for Neglected Diseases initiative, Geneva, Switzerland.
Yves JacksonDivision of Primary Care Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Leanne B OhlundChemistry Department, Université du Québec à Montréal, Montreal, Quebec, Canada.
Asieh RasoolizadehNational Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Fabio Vasquez CamargoNational Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Louiza MahroucheChemistry Department, Regional Centre for Mass Spectrometry, Université de Montréal, Montreal, Quebec, Canada.
Alexandra FurtosChemistry Department, Regional Centre for Mass Spectrometry, Université de Montréal, Montreal, Quebec, Canada.
Lekha SlenoChemistry Department, Université du Québec à Montréal, Montreal, Quebec, Canada.
Momar NdaoNational Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
McGill University Health Centre · CAUniversité de Montréal · CAUniversité du Québec à Montréal · CAConcordia University of Edmonton · CADrugs for Neglected Diseases Initiative · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causative agent of Chagas disease (CD),

Indexed as

Biomarker discoveryChagas diseaseGlutamineMass spectrometryMetabolomicsMouse modelPhenylalanyl-threonineProteomicsPyroglutamyl-glycineSex steroidsTaurineTestisTestosteroneTrypanosoma cruzi

Identifiers

PMID36590505
PMCPMC9800200
OpenAlexW4311774295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.