ArticleClinical parkinsonism & related disorders2023
Severity of depressive and motor symptoms impacts quality of life in Parkinson's disease patients at an academic movement clinic: A cross-sectional study.
Article in Clinical parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effects of different exercises on motor and non-motor abilities in patients with Parkinson disease-a network meta-analysis of randomized controlled trials.Frontiers in physiology · 2026Pooled it
- The Mediating Effect of Physiological Health Fear Between Depressive Mood and Sleep Quality in Elderly Parkinson's Disease Patients.Brain and behavior · 2026Article
- Levodopa-induced alterations in vertical center of mass and muscle synergy structure during Parkinsonian gait.Experimental brain research · 2026Article
- Depression and Mood Changes in People with Parkinson's Disease over Time: A 5-Year Follow-Up Study.Journal of personalized medicine · 2026Article
- Investigating Disordered Eating Behaviours Among Individuals Living With Neurodegenerative Disease: A Scoping Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Article
- Psychiatric Comorbidity, Tic Severity and Quality of Life in Adults with Tourette's Syndrome.Movement disorders clinical practice · 2026Article
- Influence of Age on the Effectiveness of Lee Silverman Voice TreatmentGeriatrics (Basel, Switzerland) · 2026Article
- Differential Proteomic Landscape of Plasma Neuron-Derived Extracellular Vesicles in Parkinson's Disease with and without RBD: A Pilot Investigation.International journal of nanomedicine · 2026Article
- Depression and cognition mediated rapid eye movement sleep behavior disorder to improve the activities of daily living in Parkinson's disease patients.Frontiers in psychiatry · 2026Article
- The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank.NPJ Parkinson's disease · 2025Article
- Mental Health and Well-Being of Residents with Parkinson's Disease in Care Homes: A Scoping Review.Healthcare (Basel, Switzerland) · 2025Review
- Longitudinal dynamics of clinical and neurophysiological changes in parkinson's disease over four and a half years.Scientific reports · 2025Article
- Examining the Relationship Between Physical Function and Anxiety/Depression in Parkinson's.Brain and behavior · 2025Article
- Effects of puerarin on gait disturbance in a 6-hydroxydopamine mouse model of Parkinson's disease.Pharmacological reports : PR · 2025Article
- Decreased resting-state functional connectivity and brain network abnormalities in the prefrontal cortex of elderly patients with Parkinson's disease accompanied by depressive symptoms.Global health & medicine · 2024Article
- Article
- Pain Fluctuations in Parkinson's Disease and Their Association with Motor and Non-Motor Fluctuations.Journal of Parkinson's disease · 2024Observational
- Parkinson's Disease: A Narrative Review on Potential Molecular Mechanisms of Sleep Disturbances, REM Behavior Disorder, and Melatonin.Brain sciences · 2023Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Parkinson's disease (PD) is a neurodegenerative disease with motor and non-motor manifestations that have been previously reported to affect patient quality of life (QoL). Our objective is to investigate the factors that contribute to QoL in a cohort of PD patients receiving care at a major academic institution. Methods: In this cross-sectional study of 124 participants (71.77% male, mean age 65.20, mean UPDRS-III score 11.25), we analyzed if certain clinical features such as UPDRS-III, QIDS-C, and total disease duration contributed to QoL as measured by two different metrics (PDQ-39 and EQ-5D) in PD patients at a university Movement Disorders Clinic. Results: Motor symptoms of PD, with the exception of tremor, as well as depression and specific depressive symptoms were significantly and positively correlated with lower QoL metrics for patients with Parkinson's, with total depressive symptom severity (QIDS-C Conclusion: While severity of motor symptoms certainly impacted QoL in our cohort, our findings suggest that depressive symptoms contribute more to impaired QoL than severe motor symptoms do. This phenomenon suggests that concomitant depression in PD as well as one's psychological adjustment to disability may have a greater impact on QoL than severe motor symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.