Evidence map›Paper›PMID 36590323›Full record

ArticleJHEP reports : innovation in hepatology2023

Metabolic reprogramming of hepatocytes by

Verena von Bülow, Sarah Gindner, Anne Baier, Laura Hehr, Nicola Buss, Lena Russ, Sarah Wrobel, Victoria Wirth, Kuscha Tabatabai, Thomas Quack and 16 more

Open access · goldAbstract read
In one paragraph

Article in JHEP reports : innovation in hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Interleukin13 Ameliorates Hepatocellular Steatosis via IL13Rα1/JNK/FOSL2 Signaling Pathway.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Implications of host sex on liver metabolism duringFrontiers in cellular and infection microbiology · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Pharmacological Inhibition of c-Jun N-Terminal Kinase Activity Exacerbates Liver Damage in Schistosoma mansoni Infected Mice.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  11. Article
  12. Article
  13. Differential murine responses toInfection and immunity · 2024
    Article
  14. Article
  15. Article
  16. Hepatic Topology of Glycosphingolipids inAnalytical chemistry · 2024
    Article
  17. Review
  18. PNAS nexus · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 2 countries.

Verena von BülowDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Sarah GindnerDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Anne BaierDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Laura HehrDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Nicola BussDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Lena RussDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Sarah WrobelDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Victoria WirthDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Kuscha TabatabaiDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Thomas QuackInstitute of Parasitology, BFS, Justus Liebig University, Schubertstr. 81, 35392 Giessen, Germany.
Simone HaeberleinInstitute of Parasitology, BFS, Justus Liebig University, Schubertstr. 81, 35392 Giessen, Germany.
Patrik KadeschInstitute of Inorganic and Analytical Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Stefanie GerbigInstitute of Inorganic and Analytical Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Katja R WiedemannInstitute of Inorganic and Analytical Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Bernhard SpenglerInstitute of Inorganic and Analytical Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Annabel MehlInstitute of Nutritional Science, Food Science Department, and Interdisciplinary Research Center (iFZ), Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
Gertrud MorlockInstitute of Nutritional Science, Food Science Department, and Interdisciplinary Research Center (iFZ), Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
Gabriele SchrammExperimental Pneumology, Priority Research Area Asthma & Allergy, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany.
Jörn Pons-KühnemannInstitute of Medical Informatics, Justus Liebig University, Rudolf-Buchheim-Str. 6. 35392 Giessen, Germany.
Franco H FalconeInstitute of Parasitology, BFS, Justus Liebig University, Schubertstr. 81, 35392 Giessen, Germany.
R Alan WilsonYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
Katrin BankovDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Peter WildDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Christoph G GreveldingInstitute of Parasitology, BFS, Justus Liebig University, Schubertstr. 81, 35392 Giessen, Germany.
Elke RoebDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Martin RoderfeldDepartment of Gastroenterology, Justus Liebig University, Klinikstr. 33, 35392 Giessen, Germany.
Justus-Liebig-Universität Gießen · DEGoethe University Frankfurt · DEResearch Center Borstel - Leibniz Lung Center · DEUniversity of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Schistosomiasis is a parasitic infection which affects more than 200 million people globally. Methods: Metabolic reprogramming was analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging, liquid chromatography with high-resolution mass spectrometry, metabolite quantification, confocal laser scanning microscopy, live cell imaging, quantitative real-time PCR, western blotting, assessment of DNA damage, and immunohistology in hamster models and functional experiments in human cell lines. Major results were validated in human biopsies. Results: The infection with Conclusions: Our findings indicate that Impact and implications: The authors demonstrate that soluble egg products of the parasite

Indexed as

bs, bisexDMPE, dimethyl-phosphatidylethanolamineDNA damageflOA, fluorescently labelled OAGS, glycogen synthaseGSH, reduced L-glutathioneHCC, hepatocellular carcinomahRF, retention factor ∗ 100LipidMALDI-MSI, matrix assisted laser desorption/ionization mass spectrometry imagingMDA, malondialdehydems, monosexni, non-infectedOA, oleic acidOxidative stressParasitePAS, periodic acid-SchiffPC, phosphatidylcholinePDH, pyruvate dehydrogenasePE, phosphatidylethanolaminePLIN2, perilipin 2ROS, reactive oxygen speciesSchistosomiasisSEA, soluble egg antigensS. japonicum, Schistosoma japonicumS. mansoni, Schistosoma mansoniTG, triglyceride

Identifiers

PMID36590323
PMCPMC9800334
OpenAlexW4308476982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.