ArticleFrontiers in nutrition2022
Causal effect of iron status on lung function: A Mendelian randomization study.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Review
- Mendelian Randomization Analysis of Systemic Iron Status and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease.Metabolites · 2026Article
- Integrative analysis of vitamin D, ferritin, and eosinophilic inflammation in predicting acute exacerbations of childhood asthma.Frontiers in immunology · 2026Article
- Association between BRINDA-corrected iron metabolism and lung function in the community: the CoLaus|PneumoLaus study.BMC pulmonary medicine · 2025Observational
- Unlocking iron: nutritional origins, metabolic pathways, and systemic significance.Frontiers in nutrition · 2025Review
- Malnutrition and Allergies: Tipping the Immune Balance towards Health.Journal of clinical medicine · 2024Review
- Assessing the causal role of physical activity and leisure sedentary behaviours with chronic obstructive pulmonary disease: a Mendelian randomisation study.BMJ open respiratory research · 2024Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Background: The association between systemic iron status and lung function was conflicting in observational studies. We aim to explore the potential causal relationships between iron status and the levels of lung function using the two-sample Mendelian randomization (MR) design. Methods: Genetic instruments associated with iron status biomarkers were retrieved from the Genetics of Iron Status (GIS) consortium ( Results: Based on conservative genetic instruments, MR analyses showed that genetically predicted higher iron (beta: 0.036 per 1 SD increase, 95% confidence interval (CI): 0.016 to 0.056, Conclusion: Our study provided strong evidence to support that higher iron status is causally associated with higher levels of FEV1 and FVC, but has no impact on airway obstruction, confirming iron status as an important target for lung function management.
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Registered trials
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