Evidence map›Paper›PMID 36590168›Full record

ArticleiScience2023

Depletion of HIV reservoir by activation of ISR signaling in resting CD4

Dajiang Li, Lilly M Wong, Yuyang Tang, Brigitte Allard, Katherine S James, George R Thompson, Satya Dandekar, Edward P Browne, Qingsheng Li, Jeremy M Simon and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Dajiang LiUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Lilly M WongUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Yuyang TangUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Brigitte AllardUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Katherine S JamesUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
George R ThompsonDepartment of Medical Microbiology, the University of California at Davis, Davis, CA 95616, USA.
Satya DandekarDepartment of Medical Microbiology, the University of California at Davis, Davis, CA 95616, USA.
Edward P BrowneUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Qingsheng LiSchool of Biological Sciences and Nebraska Center for Virology, the University of Nebraska-Lincoln, Lincoln, NE 68588-0118, USA.
Jeremy M SimonDepartment of Genetics, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Nancie M ArchinUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
David M MargolisUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
Guochun JiangUNC HIV Cure Center, Institute of Global Health and Infectious Diseases, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7042, USA.
University of North Carolina at Chapel Hill · USUniversity of Nebraska–Lincoln · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
POLYCOMB REPRESSIVE COMLEXE AS KEY REGULATORS OF HIV LATENCY AND TARGETS FOR LATENCY REVERSALR61DA047023 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JAMES, LINDSEY INGERMAN · 2018 to 2020
$2.7M
Defining the impact of cannabinoids on the latent HIV reservoir through multi-omic analysisR61DA053599 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BROWNE, EDWARD P · 2021 to 2023
$2.0M
Regulation of HIV Latency by Host Cell Transcriptional and Epigenetic NetworksR01AI143381 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BROWNE, EDWARD P · 2019 to 2022
$1.6M
Characterize replication competent myeloid reservoirs in the central nervous systemR21MH128034 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIANG, GUOCHUN · 2021 to 2022
$443k
NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI143381NIAID NIH HHS UM1 AI164567NIDA NIH HHS R61 DA047023NIDA NIH HHS R61 DA053599NIMH NIH HHS R21 MH128034
6 · The paper itself

Abstract

HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4

Indexed as

ImmunologyTranscriptomicsVirology

Identifiers

PMID36590168
PMCPMC9800255
OpenAlexW4313420065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.