Evidence map›Paper›PMID 36590091›Full record

ArticleIBRO neuroscience reports2022

Fingolimod increases parvalbumin-positive neurons in adult mice.

Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hiroshi UenoDepartment of Medical Technology, Kawasaki University of Medical Welfare, Kurashiki 701-0193, Japan.
Yu TakahashiDepartment of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Shinji MurakamiDepartment of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Kenta WaniDepartment of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Yosuke MatsumotoDepartment of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Motoi OkamotoDepartment of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.
Takeshi IshiharaDepartment of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Kawasaki Medical School · JPOkayama University · JPKawasaki University of Medical Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, it has been shown that central nervous system agents, such as antidepressants and antiepileptic drugs, reopen a critical period in mature animals. Fingolimod, which is used for the treatment of multiple sclerosis, also restores neuroplasticity. In this study, we investigated the effects of parvalbumin (PV)-positive neurons and perineuronal nets (PNN) on fingolimod administration with respect to neuroplasticity. Fingolimod was chronically administered intraperitoneally to mature mice. PV-positive neurons and PNN in the hippocampus, prefrontal cortex, and somatosensory cortex were analyzed. An increase in PV-positive neurons was observed in the hippocampus, prefrontal cortex, and somatosensory cortex of the fingolimod-treated mice. An increase in

Indexed as

CNS, central nervous systemdAC, dorsal anterior cingulate cortexECM, extracellular matrixFingolimodGAD67, anti-glutamic acid decarboxylaseGFAP, glial fibrillary acidic proteinHippocampusIL, infralimbic cortexNIH, National Institutes of Health, PBS, phosphate-buffered salineParvalbuminPerineuronal netsPL, prelimbic cortexPNN, perineuronal netPrefrontal cortexPV neurons, parvalbumin-expressing interneuronsSomatosensory cortexWFA, Wisteria floribunda agglutinin

Identifiers

PMID36590091
PMCPMC9795291
OpenAlexW4283738582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.