Evidence map›Paper›PMID 36589903›Full record

ArticleAdvanced functional materials2022

Jeff W M Bulte, Chao Wang, Ali Shakeri-Zadeh

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Recent advances in non-invasiveBiomaterials science · 2025
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeff W M BulteRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chao WangRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ali Shakeri-ZadehRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins University · US

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor TherapyR01EB030376 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2020 to 2024
$2.1M
Label-Free Imaging of Composite Hyaluronic Acid Hydrogels in Regenerative MedicineR01EB023647 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2017 to 2020
$1.5M
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSUH3EB028904 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2021 to 2022
$950k
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
NCI NIH HHS R01 CA257557NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB023647NIBIB NIH HHS R01 EB030376NIBIB NIH HHS UH3 EB028904NIH HHS S10 OD026740
6 · The paper itself

Abstract

Superparamagnetic iron oxide (SPIO)-labeling of cells has been applied for magnetic resonance imaging (MRI) cell tracking for over 30 years, having resulted in a dozen or so clinical trials. SPIO nanoparticles are biodegradable and can be broken down into elemental iron, and hence the tolerance of cells to magnetic labeling has been overall high. Over the years, however, single reports have accumulated demonstrating that the proliferation, migration, adhesion and differentiation of magnetically labeled cells may differ from unlabeled cells, with inhibition of chondrocytic differentiation of labeled human mesenchymal stem cells (hMSCs) as a notable example. This historical perspective provides an overview of some of the drawbacks that can be encountered with magnetic labeling. Now that magnetic particle imaging (MPI) cell tracking is emerging as a new

Indexed as

cell trackingimmune cellsmagnetic particle imagingMagnetic resonance imagingstem cellssuperparamagnetic iron oxide nanoparticles

Identifiers

PMID36589903
PMCPMC9798832
OpenAlexW4293254701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.