ArticleFrontiers in endocrinology2022
Association between the metabolic score for insulin resistance (METS-IR) and estimated glomerular filtration rate (eGFR) among health check-up population in Japan: A retrospective cross-sectional study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- Non-insulin-dependent insulin resistance surrogate indexes for predicting chronic kidney disease in diabetic individuals: a prospective cohort study.BMC endocrine disorders · 2026Article
- A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study.Frontiers in cardiovascular medicine · 2026Article
- A Nonlinear Association Between Gamma-Glutamyltransferase to High-Density Lipoprotein Cholesterol Ratio and Arterial Stiffness in Japanese Population: A Secondary Analysis Based on a Cross-Sectional Study.Vascular health and risk management · 2026Article
- Estimated Glomerular Filtration Rate and Incident Prediabetes Risk in Normoglycemic Adults With Parental Type 2 Diabetes.Journal of the Endocrine Society · 2025Article
- The association of the metabolic score for insulin resistance and metabolic dysfunction-related steatosis liver disease: a population-based observational study.European journal of medical research · 2025Observational
- Association between insulin resistance and multiple chronic diseases: a cross-sectional study from CHARLS.Journal of health, population, and nutrition · 2025Article
- Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study.Frontiers in nutrition · 2025Article
- Comparison of the predictive value of different non-insulin-based insulin resistance indices for acute kidney injury in patients with sepsis: a retrospective study.Frontiers in endocrinology · 2025Article
- The U-shape relationship between insulin resistance-related indexes and chronic kidney disease: a retrospective cohort study from National Health and Nutrition Examination Survey 2007-2016.Diabetology & metabolic syndrome · 2024Article
- Association between metabolic score for insulin resistance and clinical outcomes: insights from the Tehran lipid and glucose study.Nutrition & metabolism · 2024Article
- The Association of the Metabolic Score for Insulin Resistance (METS-IR) with Prehypertension in Normoglycemic Individuals.International journal of endocrinology and metabolism · 2024Article
- Comparison of METS-IR and HOMA-IR for predicting new-onset CKD in middle-aged and older adults.Diabetology & metabolic syndrome · 2023Article
- Association between the metabolic score for insulin resistance (METS-IR) and arterial stiffness among health check-up population in Japan: a retrospective cross-sectional study.Frontiers in endocrinology · 2023Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Aim: This study aimed to investigate the relationship between a new metric-metabolic score for insulin resistance (METS-IR)-and estimated glomerular filtration rate (eGFR) among Japanese participants who underwent health check-ups. Methods: We conducted a cross-sectional study that involved participants in a medical health screening program, which was conducted at the Medical Health Check-up Center in Japan. This retrospective study examined the relationship between METS-IR and eGFR among 881 individuals that joined the program between March 1, 2004, and December 31, 2012. Covariates consisted of serum laboratory tests and lifestyle questionnaires. Multivariate linear regression analysis was used to explore the association between METS-IR and eGFR. In addition, subgroup and interaction analyses were done based on age, sex, body mass index (BMI), alcohol use, smoking status, and hyperuricemia. Results: A total of 881 individuals participated in this study. High METS-IR was highly linked with reduced eGFR (adjusted β = -5.04, 95% confidence interval (CI): -7.65 to -2.43), while METS-IR was utilized as a categorical variable inside the multiple regression analysis. A decrease in eGFR of 2.54 units was reported for every 10-unit rise in METS-IR (adjusted β = -2.54, 95% CI: -4.04 to -1.05, Conclusions: METS-IR is remarkably associated with eGFR among the participants who underwent health check-ups in Gifu, Japan. Although more studies are required to prove it, METS-IR could be applied as a monitoring index for early screening, primary prevention, and diagnostic and treatment management strategies for chronic kidney disease.
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